2012
DOI: 10.1097/hjh.0b013e328353824b
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Liver growth factor treatment reverses vascular and plasmatic oxidative stress in spontaneously hypertensive rats

Abstract: LGF treatment of SHRs normalizes the level of plasma oxidative stress biomarkers through a reduction of vascular superoxide anion produced by NADPH and xanthine oxidases. These effects might be linked to the cardiovascular regenerative actions of LGF.

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Cited by 19 publications
(20 citation statements)
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“…Systolic and diastolic blood pressures (SBP and DBP, respectively) and heart rate (HR) were measured in rats under anesthesia (ketamine 80 mg/kg-xylacine 10 mg/kg, i.p) as previously described [27]. Briefly, a cannula connected to a pressure transducer (Statham; Harvard Apparatus) was inserted in the right iliac artery and pressure wave was recorded in a PowerLab system (ADInstruments) during 60 minutes.…”
Section: Blood Pressure Measurementsmentioning
confidence: 99%
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“…Systolic and diastolic blood pressures (SBP and DBP, respectively) and heart rate (HR) were measured in rats under anesthesia (ketamine 80 mg/kg-xylacine 10 mg/kg, i.p) as previously described [27]. Briefly, a cannula connected to a pressure transducer (Statham; Harvard Apparatus) was inserted in the right iliac artery and pressure wave was recorded in a PowerLab system (ADInstruments) during 60 minutes.…”
Section: Blood Pressure Measurementsmentioning
confidence: 99%
“…Plasma protein carbonyls were assessed with a 2,4 dinitrophenylhydrazine-based assay [28], as previously described [27]. The protein carbonyl concentration was determined using extinction coefficient of 2,4-dinitrophenylhydrazine (ε 22000 M/cm) and expressed as nmol/mg protein.…”
Section: Total Protein Carbonylsmentioning
confidence: 99%
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“…O aumento dos danos observados em nosso estudo também pode ser observado em outros modelos de doença crônica como o modelo experimental de hipertensão (SHR) (CONDEZO-HOYOS et al, 2012). Vale ressaltar ainda que houve redução da GPx e da CAT nos animais obesos sugerindo prejuízo marcante no equilíbrio redox nos animais obesos.…”
Section: Vfc Representa Um Mau Prognóstico (Ribeiro and Moraes Filho 2unclassified