Liver graft outcomes from donors with vaccine induced thrombosis and thrombocytopenia (VITT): United Kingdom multicenter experience

Kidney transplantation from deceased donors with vaccine‐induced thrombosis and thrombocytopenia (VITT): Definitely feasible and safe?

“…Last, what we have learned with the VITT experience could be easily translated in case of immune thrombocytopenic purpura (ITP)‐deceased donors, although TMA, in analogy to what was recently observed with VITT cases, 8 is uncommon in kidney transplantation compared to liver transplantation due to a lower passenger lymphocyte burden 9 …”

“…Last, what we have learned with the VITT experience could be easily translated in case of immune thrombocytopenic purpura (ITP)deceased donors, although TMA, in analogy to what was recently observed with VITT cases, 8 is uncommon in kidney transplantation compared to liver transplantation due to a lower passenger lymphocyte burden. 9 This is of relevance taking into account that the currently and worldwide used mRNA-based anti-SARS-CoV-2 vaccines were not associated with VITT occurrence, whereas both cases of de novo and of exacerbation of preexisting ITP were reported.…”

Kidney Transplantation From Deceased Donors With Vaccine-induced Immune Thrombocytopenia and Thrombosis: An Updated Analysis of the UK Experience

“…Our findings advance existing knowledge and provide reasonable reassurance that good outcomes are likely after kidney transplantation from donors with VITT. 5,6,8,23 There remains an ongoing need for vigilance for donor-related complications in these recipients.…”

“…Earlier reports from the period when VITT was emerging as a novel clinical syndrome found some catastrophic early complications in recipients of liver transplants from donors with VITT, 5,8 resulting in a moratorium on liver transplants from these donors in the United Kingdom except in exceptional circumstances. 12 Although the follow-up is relatively short, our results in kidney transplant recipients are reassuring, with outcomes comparable with national data and no evidence of transmitted disease.…”

“…The outcomes of liver transplants in the United Kingdom from donors with VITT have been reported elsewhere. 8 In this study, we analyzed outcomes in all UK kidney transplant recipients since the syndrome emerged, focusing on postoperative complications, patient and graft survival, and looking specifically for evidence of disease transmission.…”