Liver Glycogen Synthesis and Glucose Tolerance in Rats Adapted to Diets with a High Proportion of Fructose or Glucose

Vr&aacute;na, A.; F&aacute;bry, P.; Kazdov&aacute;, L.

doi:10.1159/000176221

Cited by 17 publications

(1 citation statement)

References 10 publications

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“…However, after 30 weeks of the HFS diet, 20:4(n-6) levels increased, suggesting that this prevention declines over time. Interestingly, other studies have reported an adaptive response of blood pressure and an enzyme adaptation in lipid and carbohydrate metabolism among the long-term effects of a high-fructose diet (Vraná et al, 1978;Mayes and Laker, 1986;Park and Meyer, 1992;Dai and McNeill, 1995;Takagawa et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Long-term high fructose and saturated fat diet affects plasma fatty acid profile in rats

Tranchida

Tchiakpe

Rakotoniaina

et al. 2012

J. Zhejiang Univ. Sci. B

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Abstract:As the consumption of fructose and saturated fatty acids (FAs) has greatly increased in western diets and is linked with an increased risk of metabolic syndrome, the aim of this study was to investigate the effects of a moderate (10 weeks) and a prolonged (30 weeks) high fructose and saturated fatty acid (HFS) diet on plasma FA composition in rats. The effects of a few weeks of HFS diet had already been described, but in this paper we tried to establish whether these effects persist or if they are modified after 10 or 30 weeks. We hypothesized that the plasma FA profile would be altered between 10 and 30 weeks of the HFS diet. Rats fed with either the HFS or a standard diet were tested after 10 weeks and again after 30 weeks. After 10 weeks of feeding, HFS-fed rats developed the metabolic syndrome, as manifested by an increase in fasting insulinemia, total cholesterol and triglyceride levels, as well as by impaired glucose tolerance. Furthermore, the plasma FA profile of the HFS group showed higher proportions of monounsaturated FAs like palmitoleic acid [16:1(n-7)] and oleic acid [18:1(n-9)], whereas the proportions of some polyunsaturated n-6 FAs, such as linoleic acid [18:2(n-6)] and arachidonic acid [20:4(n-6)], were lower than those in the control group. After 30 weeks of the HFS diet, we observed changes mainly in the levels of 16:1(n-7) (decreased) and 20:4(n-6) (increased). Together, our results suggest that an HFS diet could lead to an adaptive response of the plasma FA profile over time, in association with the development of the metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%