Liver Function Tests in Chronic Congestive Heart Failure

Felder, Leonard; Mund, Alvin; Parker, Julius G.

doi:10.1161/01.cir.2.2.286

Cited by 54 publications

(16 citation statements)

References 3 publications

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“…The occurrence of jaundice in patients with both acute and chronic heart failure has been noted for many years (Jolliffe, 1930;Kugel and Lichtman, 1933;Felder, Mund, and Parker, 1950;Sherlock, 1951;Evans, Zimmerman, Wilmer, Thomas, and Ethridge, 1952;White, Leevy, Brusca, and Gnassi, 1955;Richman, Delman, and Grob, 1961). Jaundice following non-cardiac surgery and injury has also been reported (Geller and Tagnon, 1950;Sevitt, 1958;Pichlmayr and Stich, 1962;Schmid, Hefti, Gattiker, Kistler, and Senning, 1965).…”

mentioning

confidence: 99%

Early jaundice after open-heart surgery

Lockey¹,

McIntyre²,

Ross³

et al. 1967

Thorax

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Two hundred and thirty-two patients subjected to open-heart surgery have been analysed regarding early post-operative jaundice. The overall incidence of jaundice was 13%, being 55% where the mitral valve and 5% where the aortic valve was predominantly involved. Only one out of 59 patients in whom a congenital lesion was repaired became jaundiced. Hyperbilirubinaemia without jaundice was common. The biochemical pattern of the jaundice was singularly constant, the most striking feature being the rise in serum bilirubin level. The highest value occurred between the second and tenth post-operative days. At total levels less than about 4 mg. /100 ml. the unconjugated fraction usually equalled or exceeded the conjugated. The alkaline phosphatase was normal in the first post-operative week but was sometimes slightly raised in the second, when the bilirubin levels were usually falling. The S.G.P.T. was normal or very slightly raised. Bilirubinuria was present. Centrilobular congestion with no evidence of extrahepatic biliary obstruction was found at post-mortem examination, and liver biopsy in three very severely jaundiced patients revealed only intrahepatic cholestasis. Pre-operative evidence of liver dysfunction was found in 13 patients who subsequently became jaundiced. Twelve had lesions predominantly affecting the mitral valve. Haemolysis, heart failure, and infection probably all played a part, and the effect of operation per se on liver function has been discussed. Drugs and viral hepatitis do not seem implicated in our patients. Maintenance of lower venous pressures in the post-operative period and the use of less blood reduced both the incidence and severity of jaundice.

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confidence: 99%

Early jaundice after open-heart surgery

Lockey¹,

McIntyre²,

Ross³

et al. 1967

Thorax

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“…Fredericks & Hoffbauer (1945) found that in eleven subjects receiving malarial therapy, BSP retention occurred in eight ;Felder, Mund & Parker (1950) observed that in 135 cases of 'chronic protracted congestive heart failure' BSP clearance was 'normal in 85 % of the determinations', and Jolliffe (1930) found no constant relation between the clinical state of patients in heart failure and the BSP clearance.…”

mentioning

confidence: 99%

The effect upon bromsulphalein extraction of the rate and distribution of blood flow in the perfused canine liver

Andrews¹,

Maegraith²,

Richards³

1956

The Journal of Physiology

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“…[6][7][8][9][10][11][12][13][14] ). Concerning T-BIL, according Shinigava et al the prevalence of abnormal serum levels was much higher (64%) compared to work of Lau et al (19%) and this study (34%).…”

Section: Discussionmentioning

confidence: 99%

“…Strikingly, there are only few works investigating the liver involvement in AHF (Table 1) (ref. [6][7][8][9][10][11][12][13][14]. The aim of this study was to evaluate the prevalence of LFTs abnormalities and to identify associated cardiac and noncardiac factors mediating hepatic impairment in AHF -new onset (de novo) heart failure as well as acute exacerbation of chronic.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

Vyskočilová¹,

Špinarová²,

Špinar³

et al. 2015

BIOMED PAP

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Aims. Liver pathology caused by cardiac dysfunction is relatively well recognized, however, its clinical importance has not been fully evaluated. The aim of this study was to assess the prevalence of liver function tests (LFTs) abnormalities and to identify associated factors mediating hepatic impairment in patients with acute heart failure (AHF). Methods. The AHEAD (Acute Heart Failure Database) registry is a database conducted in 9 university hospitals and 5 regional health care facilities in the Czech Republic. From December 2004 to October 2012, the data of 8818 patients were included. The inclusion criteria for the database followed the European guidelines for AHF. Serum activities of all LFTs and total bilirubin were available in 1473 patients at the baseline. Results. In patients with AHF, abnormal LFTs were seen in 76% patients (total bilirubin in 34%, γ-glutamyltransferase in 44%, alkaline phosphatase in 20%, aspartate aminotransferase in 42%, alanine aminotransferase in 35%). Patients with cardiogenic shock were more likely to have LFTs abnormalities compared to mild AHF and pulmonary oedema. LFTs abnormalities were strongly associated with AHF severity (left ventricular ejection fraction and NYHA functional class) and clinical manifestation. While hepatocellular LFTs pattern predominated in left sided forward AHF, cholestatic profile occurred mainly in bilateral and right sided AHF. Additionally, patients with moderate to severe tricuspid regurgitation had significantly higher prevalence of abnormalities in cholestatic LFTs. Conclusions. Defining the LFTs profile typical for AHF plays an important role in management of AHF patients, since it may avoid redundant hepatic investigations and diagnostic misinterpretations.

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Liver Function Tests in Chronic Congestive Heart Failure

Cited by 54 publications

References 3 publications

Early jaundice after open-heart surgery

Early jaundice after open-heart surgery

The effect upon bromsulphalein extraction of the rate and distribution of blood flow in the perfused canine liver

Prevalence and clinical significance of liver function abnormalities in patients with acute heart failure

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