Liver function alterations in synthetic leather workers exposed to dimethylformamide

Fiorito, A; Larese, F; Molinari, Stefania; Zanin, Tina

doi:10.1002/(sici)1097-0274(199709)32:3<255::aid-ajim11>3.0.co;2-u

Cited by 64 publications

(29 citation statements)

References 20 publications

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“…The hepatotoxicity of DMF has been demonstrated in various studies in animal experiments with various species and in epidemiology studies (Massmann 1956;Martelli 1960;Schottek 1970;Tanaka 1971;Potter 1973;Lundberg et al 1981Lundberg et al , 1983Craig et al 1984;Kennedy and Sherman 1986;Scailteur and Lauwerys 1987;Redlich et al 1988Redlich et al , 1990Fleming et al 1990;Hurtt et al 1991Hurtt et al , 1992IPCS 1991;Wang et al 1991;Cai et al 1992;Imazu et al 1992;Lewis et al 1992;Chieli et al 1995;Fiorito et al 1997). The hepatotoxic eects correspond to a fatty degeneration of the liver cells, often with a clinically asymptomatic course.…”

Section: Introductionmentioning

confidence: 99%

Liver function in workers exposed to N , N -dimethylformamide during the production of synthetic textiles

Wrbitzky¹

1999

International Archives of Occupational and Environmental Health

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In this study we tried to differentiate and quantify the interaction between DMF exposure and alcohol consumption and the influence of both substances on liver function. The experience gained from former occupational health surveillance in DMF-exposed persons and from the present study show that there are individual differences in tolerance of interactions between DMF and ethyl alcohol. Further studies are necessary for the evaluation of these individual degrees of susceptibilitiy.

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Section: Introductionmentioning

confidence: 99%

Liver function in workers exposed to N , N -dimethylformamide during the production of synthetic textiles

Wrbitzky¹

1999

International Archives of Occupational and Environmental Health

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“…He also reported a signi®cant link between elevated creatine phosphokinase (CPK) levels and DMF exposure. A cross-sectional study by Fiorito et al (1997) of the prevalence of chronic liver dysfunction among 75 synthetic leather factory employees showed that DMF exposure can cause liver disease even if air threshold limit values (TLVs) are respected. Liver abnormalities were due to accidental contact with liquid DMF that signi®cantly increased DMF uptake.…”

Section: Introductionmentioning

confidence: 99%

Exposure to solvents in a synthetic leather manufacturing plant

Kuo¹,

Huang²,

et al. 2000

International Archives of Occupational and Environmental Health

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The objective of this study was to evaluate the exposure of synthetic leather workers to dimethylformamide (DMF), epichlorohydrin (ECH) and toluene, in a manufacturing plant. The correlation between biological and environmental monitoring for DMF was also investigated. Environmental monitoring of the three solvents included personal and area sampling based on time of day (morning and afternoon). Urine samples were taken at the end of the shift and urinary N-methylformamide (NMF) was then used to biologically monitor DMF levels. Results for solvent concentrations based on air sampling were considerably higher in area than in personal sampling. Of 41 area samples, 15 (36.6%) and five (12.2%) exceeded permissible exposure levels for DMF and ECH, respectively, compared with 22 (28.6%) and three (3.9%) based on 77 personal samples. Overall, urinary NMF concentrations were lower than the Biological Exposure Index (BEI) suggested by the American Conference of Governmental Industrial Hygienists (ACGIH). A significant correlation (r = 0.32; P < 0.05) was found between environmental and biological monitoring. Even though urinary NMF concentration was within permissible levels for Taiwan, the authors recommend that immediate measures be taken to decrease DMF and ECH concentrations in synthetic leather manufacturing plants.

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“…The hepatotoxicity of DMF has been demonstrated in various animal and epidemiological studies (3)(4)(5)(6)(7)(8)(9)(10)(11). The severity of the liver injury is directly related to dose; however, exposure to DMF can cause symptoms even at low concentrations (12 T a b l e 1 .…”

Section: Nn-dimethylformamide (Dmf) Is a Solvent Used Extensively Inmentioning

confidence: 99%

Occupational Liver Injury Due to N,N-Dimethylformamide in the Synthetics Industry

et al. 2009

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Liver function alterations in synthetic leather workers exposed to dimethylformamide

Cited by 64 publications

References 20 publications

Liver function in workers exposed to N , N -dimethylformamide during the production of synthetic textiles

Liver function in workers exposed to N , N -dimethylformamide during the production of synthetic textiles

Exposure to solvents in a synthetic leather manufacturing plant

Occupational Liver Injury Due to N,N-Dimethylformamide in the Synthetics Industry

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