Liver ferritin synthesis following chronic alcohol administration to rats: Modulation by propylthiouracil

Nadkarni, G.D.; Deshpande, U. R.

doi:10.1007/bf01949400

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…In rats that were chronically administered alcohol, femtin synthesis was inhibited by 22.3%. 38 Although the differences in populations noted above were statistically significant, the wide range of ferritin values in each population indicated that serum ferritin determinations would only be practical in monitoring the response of a patient to therapy using serial serum samples. This was found to be true for 25 patients from WVU.…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin as a tumor marker in patients with squamous cell carcinoma of the head and neck

Maxim¹,

Veltri²

1986

Cancer

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A double antibody enzyme immunoassay was used to measure serum ferritin levels in several different control and tumor-bearing populations collected from two institutions. The control groups consisted of normal volunteers, smokers, and Latter Day Saints. No statistically significant differences were noted in ferritin levels between pairs of these groups. Differences were noted among the normal groups when separated on the basis of age and sex, with higher ferritin levels in individuals older than 32 years of age and in men. By one-way analysis of variance, most control groups and subgroups were shown to have significantly lower levels (P < 0.05) than the head and neck cancer group, with the exception of male smokers, who had levels comparable to male head and neck cancer patients. Serum ferritin levels were higher in head and neck cancer patients than in controls; however, there was no difference when compared with patients with other types of solid malignancies or when considering the anatomic site of the head and neck lesion. Ferritin levels were significantly (P < 0.05) higher in patients with advanced (Stages 111 and IV) cancer than in those individuals with Stage I or I1 cancer. In patients with no evidence of clinical disease 5 years after treatment, the ferritin level had essentially returned to normal. In a group of head and neck cancer patients followed longitudinally, a significant decline in ferritin levels (P < 0.05) was seen by 5 months after the completion of successful treatment. Furthermore, ferritin levels showed a tendency to increase or remain at high levels in patients with a poor prognosis and to decrease in those patients with a favorable prognosis, giving support to the contention that ferritin may prove to be a valuable tumor marker in head and neck cancer. Cancer 57:305-311, 1986. URING THE COURSE of tumor development, quan-D titative changes occur in the level of a variety of substances in serum. Such substances are collectively referred to as tumor markers or biochemical serum markers, and these can be classified as belonging to one of several major groups. Examples include oncofetal proteins (car-cinoembryonic antigen [CEA], alpha-fetoprotein [AFP]), hormones (adrenocorticotropin, chorionic gonadotropin, calcitonin), enzymes (prostatic acid phosphatase), or serum proteins (beta-2 microglobulin, fenitin). Many of these markers are elevated in diseases other than cancer, and are therefore considered nonspecific, but have been From the

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Section: Discussionmentioning

confidence: 99%

Serum ferritin as a tumor marker in patients with squamous cell carcinoma of the head and neck

Maxim¹,

Veltri²

1986

Cancer

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“…Details of treatment given to adult, male Wistar rats (150-180 g) have been described recently (Nadkarni et al 1983). All the animals were given 16% protein diet (Nadkarni et al 1979a) ad libitum. Groups 111 and IV were given ethanol (20%) in drinking water for six weeks.…”

Section: Methodsmentioning

confidence: 99%

“…Rats in group IV, in addition to 20% ethanol, also received 5 mg/kg/day of PTU in drinking water during the last two weeks. All the animals were given 16% protein diet (Nadkarni et al 1979a) ad libitum. The food intake in all the groups averaged 22*3 g/rat/day.…”

Section: Methodsmentioning

confidence: 99%

“…1968). From our previous work propylthiouracil (PTU) appears to protect rats against ethanolic liver damage (Nadkarni et al 1979a & b;Nadkarni & Deshpande 1982), but this potentiation was not prevented by simultaneous treatment with PTU (Nadkarni ef al. From our previous work propylthiouracil (PTU) appears to protect rats against ethanolic liver damage (Nadkarni et al 1979a & b;Nadkarni & Deshpande 1982), but this potentiation was not prevented by simultaneous treatment with PTU (Nadkarni ef al.…”

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confidence: 99%

“…Recent work from our laboratory has shown that chronic ethanol ingestion potentiates the hepatotoxicity of galactosamine in rats (Nadkarni et al 1983). From our previous work propylthiouracil (PTU) appears to protect rats against ethanolic liver damage (Nadkarni et al 1979a & b;Nadkarni & Deshpande 1982), but this potentiation was not prevented by simultaneous treatment with PTU (Nadkarni ef al. 1983).…”

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Effect of Chronic Ethanol Ingestion on Liver and Plasma Protein Synthesis in Galactosamine‐induced Hepatitis in Rats

Nadkarni

Pestonjamasp

Deshpande

1983

Acta Pharmacologica et Toxicologica

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In rats a single injection (330 mg/kg) of D-galactosamine significantly inhibited in vivo incorporation of l4C-amino acids into fibrinogen, seromucoids and total liver proteins, but not albumin, by one third. Prior chronic exposure to ethanol (5 g/kg/day for 6 weeks) potentiated the inhibition of synthesis of all protein fractions (including albumin) up to about 50%. Propylthiouracil had no beneficial but deleterious effect against this potentiation of hepatotoxicity.

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Alcohol and Hepatic Iron Homeostasis

Potter¹

1991

Liver Pathology and Alcohol

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Liver ferritin synthesis following chronic alcohol administration to rats: Modulation by propylthiouracil

Cited by 7 publications

References 19 publications

Serum ferritin as a tumor marker in patients with squamous cell carcinoma of the head and neck

Serum ferritin as a tumor marker in patients with squamous cell carcinoma of the head and neck

Effect of Chronic Ethanol Ingestion on Liver and Plasma Protein Synthesis in Galactosamine‐induced Hepatitis in Rats

Alcohol and Hepatic Iron Homeostasis

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