Liver Failure after Major Liver Resection: Risk Assessment by Using Preoperative Gadoxetic Acid–enhanced 3-T MR Imaging

Wibmer, Andreas G.; Prusa, Alexander M.; Nolz, Richard; Gruenberger, Thomas; Schindl, Martin; Ba‐Ssalamah, Ahmed

doi:10.1148/radiology.13130210

Cited by 22 publications

(31 citation statements)

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“…Decrease of the hepatobiliary excretion of organic anions through the OATP/ MRP route in liver fibrosis, cirrhosis and non-alcoholic steatohepatitis (NASH) can be assessed with gadoxetate-enhanced MR imaging [82,[99][100][101]. Moreover, gadoxetate-enhanced MR imaging appears promising for the assessment of the risk for liver failure after major liver resection [102].…”

Section: Diffuse Liver Diseasesmentioning

confidence: 99%

New imaging techniques for liver diseases

Beers

Daire

Garteiser

2015

Journal of Hepatology

109

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Newly developed or advanced methods of ultrasonography and MR imaging provide combined anatomical and quantitative functional information about diffuse and focal liver diseases. Ultrasound elastography has a central role for staging liver fibrosis and an increasing role in grading portal hypertension; dynamic contrast-enhanced ultrasonography may improve tumor characterization. In clinical practice, MR imaging examinations currently include diffusion-weighted and dynamic MR imaging, enhanced with extracellular or hepatobiliary contrast agents. Moreover, quantitative parameters obtained with diffusion-weighted MR imaging, dynamic contrast-enhanced MR imaging and MR elastography have the potential to characterize further diffuse and focal liver diseases, by adding information about tissue cellularity, perfusion, hepatocyte transport function and visco-elasticity. The multiparametric capability of ultrasonography and more markedly of MR imaging gives the opportunity for high diagnostic performance by combining imaging biomarkers. However, image acquisition and post-processing methods should be further standardized and validated in multicenter trials.

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Section: Diffuse Liver Diseasesmentioning

confidence: 99%

New imaging techniques for liver diseases

Beers

Daire

Garteiser

2015

Journal of Hepatology

109

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“…The evaluation of liver function plays a crucial role in selecting therapeutic approaches in patients with liver tumours, monitoring patients with hepatic dysfunction, and in particular, optimizing patient selection to avoid posthepatectomy liver failure after major liver resection [14,15]. Although the causes of liver failure are multifactorial and depend on patient-related comorbidities or pre-existent liver disease, insufficient postoperative remnant liver function is one of the main contributing factors for postoperative mortality after liver resection and has become a major concern [16].…”

Section: Discussionmentioning

confidence: 99%

Volume-assisted estimation of liver function based on Gd-EOB-DTPA–enhanced MR relaxometry

et al. 2015

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• Measurement of T1 relaxation times in Gd-EOB-DTPA-enhanced MR imaging quantifies liver function. • Volume-assisted Gd-EOB-DTPA-enhanced MR relaxometry has stronger correlation with ICG-PDR than does Gd-EOB-DTPA-enhanced MR relaxometry. • Gd-EOB-DTPA-enhanced MR relaxometry may provide robust parameters for detecting and characterizing liver disease. • Gd-EOB-DTPA-enhanced MR relaxometry may be useful for monitoring liver disease progression. • Gd-EOB-DTPA-enhanced MR relaxometry has the potential to become a novel liver function index.

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“…107 The most promising liverspecific contrast agent for predicting PHLF after major liver resection is gadoxatic acid. 108 After intravenous injection, this gadolinium-based paramagnetic contrast agent is taken up by functional hepatocytes and excreted into bile ducts via membrane transporters. The temporary accumulation of this contrast agent in the liver and subsequent enhancement of the normal liver parenchyma permits the measurement of relative liver enhancement (RLE).…”

Section: Liver-specific Agents For Contrast-enhanced Mrimentioning

confidence: 99%