Liver enzymes in obstructive sleep apnoea syndrome

Abstract

Background: Obstructive sleep apnea syndrome (OSAS) is a common form of sleep disordered breathing. OSAS is associated with the cluster of metabolic abbreations that comprise the metabolic syndrome, including nonalcoholic fatty liver disease. Aims and Objectives: We investigated the effects of OSAS and its treatment with short term nasal continuous positive airway pressure (CPAP) therapy on serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Materials and Methods: We studied 20 adult males and postmenopausal female aged 50-60 years with OSAS. None had hepatitis B antigen or C antibody positive, autoimmune disease, an alcohol intake higher than 20 g/day or on regular use of hepatotoxic drugs. Abdominal ultrasound was done to establish the presence of fatty liver. Serum levels of AST and ALT were determined at baseline and after nasal CPAP treatment. Results: The baseline ALT and AST values were within normal limits. There was no significant change in ALT (25.9 ± 4.7 vs. 26.2 ± 3.4 after CPAP, P > 0.05) and AST (27.5 ± 2.0 vs. 24.6 ± 1.8, P > 0.05) values after one night of CPAP treatment. Conclusion: Serum aminotransferase may have limited use in assessing liver damage in the OSAS patients. Short term CPAP therapy doesn't seem have beneficial effects on serum aminotransferase levels in patients of OSAS.

Intermittent Hypoxia Affects the Spontaneous Differentiation In Vitro of Human Neutrophils into Long‐Lived Giant Phagocytes

“…For instance, in animal models mimicking OSA treated with NAC, oxidative stress and liver inflammation were attenuated [ 50 ], pancreatic β cells were protected from apoptosis [ 51 ], pharyngeal muscle dilator performance was also improved [ 52 ], and diaphragm muscle dysfunction was prevented [ 53 ]. In addition, oral administration of NAC to patients with OSA improved sleep efficiency, shortened the duration of apneas, decreased lipid peroxidation, and increased total reduced glutathione [ 54 ]. Taken together, these findings demonstrate the protective effects exerted by the antioxidant NAC against IH-induced oxidative stress, inflammation, and overall improving OSA associated consequences.…”

N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)

“…This condition is considered a proinflammatory vascular risk factor and NAC has been thought to improve this [ 93 ]. There are small clinical RCT trials that have shown benefit [ 94 , 95 ].…”

Sex Differences in Murine Sternohyoid Muscle Tolerance of Acute Severe Hypoxic Stress

“…Of note, contractile and endurance properties are equivalent in male and female sternohyoid muscle under control conditions. Given the association of hypoxia with oxidative/nitrosative stress and muscle functional adaptation in patients and animal models (Lavie 2003, Zhu et al 2003, Koechlin et al 2005, Ottenheijm et al 2006, Marin-Corral et al 2009, Sadasivam et al 2011, Skelly et al 2012a, Shortt et al 2014, the sex differences reported herein may relate to differences in the cellular response to redox stress. One study highlights stronger defenses against oxidative stress in female rat liver, heart, brain, and kidney tissues compared with males (Katalinic et al 2005).…”