Liver Enzymes Compared With Alcohol Consumption in Predicting the Risk of Type 2 Diabetes

Satō, Kyoko; Hayashi, Tomoshige; Nakamura, Yoshiko; Harita, Nobuko; Yoneda, Tomohiro; Endo, Ginji; Kambe, Hiroshi

doi:10.2337/dc07-2184

Cited by 66 publications

(62 citation statements)

References 23 publications

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“…Recent prospective studies have confirmed a significant association between GGT activity and the incidence of type 2 diabetes in both sexes and in various populations, including the DESIR cohort [12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m2: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

et al. 2009

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Aims/hypothesis Risk factors for incident type 2 diabetes, in particular, hepatic markers, have rarely been studied in leaner individuals. We aimed to identify the metabolic and hepatic markers associated with incident diabetes in men and women with a BMI of <27 kg/m 2 and to compare them with those in individuals with a BMI of ≥27 kg/m 2 . Methods Risk factors for 9 year incident diabetes were compared in the French Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort. Comparisons were made between the 2,947 participants with a BMI of <27 kg/m 2 and the 879 with a BMI of ≥27 kg/m 2 . Results There were 92 incident cases of diabetes in individuals with a BMI of <27 kg/m 2 and 111 in those with a BMI of ≥27 kg/m 2 . Among those who were not markedly overweight, classical biological markers were associated with 9 year incident diabetes, glycaemia being the strongest predictor. γ-Glutamyltransferase (GGT), either considered as a continuous variable or at levels ≥20 U/l, was associated with incident diabetes, with a stronger effect in the BMI <27 kg/m 2 group: OR 1.59 (95% CI 1.29-1.97, p<0.001) in comparison with OR 1.07 (95% CI 0.82-1.38, p=0.63) for those with a BMI of ≥27 kg/m 2 (results after adjustment for alcohol intake, alanine aminotransferase, waist circumference and the HOMA insulin resistance index). Conclusions/interpretation In individuals with a BMI of <27 kg/m 2 , GGT was the strongest predictor of diabetes after fasting hyperglycaemia. This association with incident diabetes remained after adjustment for conventional markers of insulin resistance, suggesting potential interactions between GGT, enhanced hepatic neoglucogenesis and/or early alterations of insulin secretion.

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Section: Discussionmentioning

confidence: 99%

Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m2: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

et al. 2009

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“…Many studies have shown that serum GGT is a biomarker of increased alcohol consumption [1][2][3][4]22) ; however, GGT is known to be affected by other con- 23,24) . Evidence is accumulating that higher serum GGT levels may be associated with an increased incidence of cardiovascular events 5) , metabolic syndrome and diabetes 8,25,26) ; therefore, more attention has been paid recently to this liver enzyme.…”

Section: Discussionmentioning

confidence: 99%

Association between Gamma-Glutamyltransferase Levels and Insulin Resistance According to Alcohol Consumption and Number of Cigarettes Smoked

Ishizaka

Toda

et al. 2010

JAT

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“…The details of the study have been described previously (18,19). Between April 2000 and March 2001, 12,647 male employees of a company in the area of Kansai, Japan, aged 40 to 55 years at entry and considered to be involved in sedentary jobs, were enrolled in this study.…”

Section: Site and Settingmentioning

confidence: 99%

Cigarette Smoking and the Association with Glomerular Hyperfiltration and Proteinuria in Healthy Middle-Aged Men

Maeda¹,

Hayashi²,

Satō³

et al. 2011

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives Glomerular hyperfiltration and albuminuria accompanied by early-stage diabetic kidney disease predict future renal failure. Cigarette smoking has reported to be associated with elevated GFR in cross-sectional studies and with renal deterioration in longitudinal studies. The degree of glomerular hyperfiltration and proteinuria associated with smoking, which presumably is a phenomenon of early renal damage, has not been investigated in a satisfying manner so far. Design, setting, participants, & measurementsThis study included 10,118 Japanese men aged 40 to 55 years without proteinuria or renal dysfunction at entry. Estimated GFR was calculated using the Modification of Diet in Renal Disease equation for Japanese. Glomerular hyperfiltration was defined as estimated GFR Ն117.0 ml/min per 1.73 m 2 , which was the upper 2.5th percentile value of estimated GFR in the total population. Proteinuria was detected using standard dipstick.Results During the 6-year observation period, there were 449 incident cases of glomerular hyperfiltration and 1653 cases of proteinuria. Current smokers had a 1.32-time higher risk for the development of glomerular hyperfiltration and a 1.51-time higher risk for proteinuria than nonsmokers after adjustment for baseline age, body mass index, systolic and diastolic BP, antihypertensive medication, diabetes, alcohol consumption, regular leisure-time physical activity, and estimated GFR. Both daily and cumulative cigarette consumption were associated with an increased risk for glomerular hyperfiltration and proteinuria in a doseresponse manner. ConclusionsIn middle-aged Japanese men, smoking was associated with an increased risk of glomerular hyperfiltration and dipstick proteinuria. Of importance, past smokers did not exhibit any increased risk for these conditions.

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Liver Enzymes Compared With Alcohol Consumption in Predicting the Risk of Type 2 Diabetes

Cited by 66 publications

References 23 publications

Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m2: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

Risk factors for incident type 2 diabetes in individuals with a BMI of <27 kg/m2: the role of γ-glutamyltransferase. Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR)

Association between Gamma-Glutamyltransferase Levels and Insulin Resistance According to Alcohol Consumption and Number of Cigarettes Smoked

Cigarette Smoking and the Association with Glomerular Hyperfiltration and Proteinuria in Healthy Middle-Aged Men

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