Liver enzymes and clustering cardiometabolic risk factors in <scp>E</scp>uropean adolescents: the <scp>HELENA</scp> study

Labayen, Idoia; Ruiz, Jonatan R.; Ortega, Francisco B.; Davis, Catherine L.; Rodríguez, G.; González‐Gross, Marcela; Breidenassel, Christina; Dallongeville, Jean; Marcos, Ascensión; Widhalm, Kurt; Kafatos, Anthony; Molnár, Denés; DeHenauw, Stefaan; Gottrand, Frédéric; Moreno, Luís A.

doi:10.1111/ijpo.273

Cited by 32 publications

(31 citation statements)

References 40 publications

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“…In youth population however, Labayen et al [ 31 ] showed a positive association between a higher number of ideal CVH metrics behaviors/factors with lower gamma-GT and ALT in 637 European adolescents. Similarly, Labayen et al [ 32 ] observed a lower aspartate aminotransferase/ALT ratio was also associated with higher cardiometabolic risk factors and their clustering in 1,084 male and female European adolescents. Regarding the FLI ( an algorithm for predicting fatty liver ), few previous studies have reported on the relationship between FLI and cardiometabolic risk factors and their clustering in adults.…”

Section: Discussionmentioning

confidence: 87%

Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009–2010)

2017

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High levels of gamma glutamyltransferase (gamma-GT) and alanine aminotransferase (ALT), as well as fatty liver index (FLI) has been associated with higher cardiovascular disease risk factors in adults. The aim of this study was to examine the relationship between gamma-GT, ALT, and fatty liver index FLI levels across a gradient number of ideal cardiovascular health metrics in a representative sample of adults from the Chilean National Health Survey 2009–2010. Data from 1,023 men and 1,449 women (≥ 15 years) from the Chilean Health Survey 2009–2010 were analyzed. Ideal cardiovascular health was defined as meeting ideal levels of the following components: four behaviours (smoking, body mass index, physical activity and diet adherence) and three factors (total cholesterol, blood pressure and fasting glucose). Adults were grouped into three categories according to their number of ideal cardiovascular health metrics: ideal (5–7 metrics), intermediate (3–4 metrics), and poor (0–2 metrics). Blood levels of gamma-GT and ALT were measured and the FLI was calculated. A higher number of ideal cardiovascular health index metric was associated with lower gamma-GT, ALT and FLI (p from trend analysis <0.001). Also, adults meeting at least 3–4 metrics were predicted less likely to have prevalence of abnormal levels of gamma-GT and FLI (p<0.001) compared to adults who met only 0–2 metrics. These findings reinforce the usefulness of the ideal cardiovascular health metrics proposed by the American Heart Association as a tool to identify target subjects and promote cardiovascular health in South-American adults.

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Section: Discussionmentioning

confidence: 87%

Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009–2010)

2017

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“…However, information regarding the distribution of liver enzymes and their association with cardiometabolic risk factors is scarce in relation to children and adolescents. 30 ALT is a specific liver enzyme that relates to the cytosolic component of hepatocytes. 5 On the other hand, other liver enzymes, including aspartate transaminase (AST), are also released from other organs such as the heart, skeletal muscles, kidneys, brain, pancreas and red blood cells.…”

Section: Discussionmentioning

confidence: 99%

“…The AST/ALT ratio thresholds for determining that adolescents presented high cardiometabolic risk were 1.00 for younger males, 0.74 for older males, 0.86 for younger females and 0.87 for older females. 30 Mohammadi et al reported that there was a strong association between high levels of ALT, AST and ALT/AST ratio and most cardiometabolic risk factors. This relationship was independent of anthropometric indexes.…”

Section: Discussionmentioning

confidence: 99%

Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study

et al. 2018

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BACKGROUND: It has been suggested that the levels of some liver enzymes, and especially alanine aminotransferase (ALT), might be correlatable with cardiometabolic risk factors. We investigated the relationship between ALT concentration and cardiometabolic risk factors among children and adolescents. DESIGN AND SETTING: This nationwide study in Iran was conducted within the framework of the fifth survey of a national surveillance program known as the Childhood and Adolescence Surveillance and PreventIon of Adult Non-communicable disease study (CASPIAN-V). METHODS: The participants comprised 4200 students aged 7-18 years, who were recruited through multi-stage random cluster sampling in 30 provinces in Iran. Physical examinations and laboratory tests were conducted in accordance with standard protocols. RESULTS: Overall, 3843 students (participation rate: 91.5%) completed the survey. Mean ALT levels were significantly higher in individuals with dyslipidemia, in terms of elevated total cholesterol (TC) or LDL-cholesterol or triglycerides (TG), excess weight and dyslipidemia. Some cardiometabolic risk factors were associated with higher levels of ALT, with the following odds ratio (OR) and 95% confidence interval (CI): metabolic syndrome (OR: 1.013; 95%

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“…It was found that elevated ALT level was weak surrogate marker for MetS and CMRF clustering. However, excess adiposity can result in hepatic insulin resistance, hepatic steatosis, and Nonalcoholic fatty liver disease (NAFLD), well-known components of MetS [ 28 , 29 ]. Some studies showed that low ALT level is associated with ideal cardiovascular health behavior [ 30 ] and MetS has been shown to have a dose-response relationship with ALT level [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Validation of surrogate markers for metabolic syndrome and cardiometabolic risk factor clustering in children and adolescents: A nationwide population-based study

Seo

Kim

2017

PLoS ONE

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Prevalence of metabolic syndrome (MetS) in children is increasing and identifying the risk factors for MetS during childhood is an important first step to prevent chronic diseases later in life. The aim of the present study was to evaluate the prevalence of MetS and cardiometabolic risk factor (CMRF) clustering among Korean children and adolescents and to validate the associated anthropometric and laboratory surrogate markers. We used data from the 2011–2014 Korean National Health and Nutrition Examination Survey. In total, data for 2,935 subjects (1539 boys, 52.6%) aged 10–19 years were assessed. MetS was defined by central obesity plus any two or more of CMRFs such as abdominal obesity, hypertension, hyperglycemia, hypertriglyceridemia, and decreased high density lipoprotein cholesterol (HDL-C) using the International Diabetes Federation criteria for children and adolescents. The presence of two or more CMRFs was classified as CMRF clustering. The prevalence of MetS and CMRF clustering in this group was found to be 1.8% and 8.9%, respectively. The receiver operating characteristic analysis of MetS and CMRF clustering, and the area under the curve (95% confidence interval) of surrogate markers revealed that the waist circumference to height ratio [0.960 (95% CI 0.959–0.960), cut-off 0.491] showed the highest predictability for MetS whereas triglyceride to HDL-C ratio [0.891 (95% CI 0.891–0.892), cut-off 2.63] showed the highest predictability for CMRF clustering. Long-term follow-up is needed for further validation.

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Liver enzymes and clustering cardiometabolic risk factors in European adolescents: the HELENA study

Cited by 32 publications

References 40 publications

Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009–2010)

Ideal cardiovascular health predicts lower risk of abnormal liver enzymes levels in the Chilean National Health Survey (2009–2010)

Association of alanine aminotransferase concentration with cardiometabolic risk factors in children and adolescents: the CASPIAN-V cross-sectional study

Validation of surrogate markers for metabolic syndrome and cardiometabolic risk factor clustering in children and adolescents: A nationwide population-based study

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