Liver donation after ethylene glycol overdose: when is it safe?

McClain, Jonathan; Uemura, Tadahiro; Sathishkumar, Subramanian; Kadry, Zakiyah

doi:10.1111/j.1432-2277.2012.01436.x

Cited by 3 publications

(3 citation statements)

References 8 publications

(8 reference statements)

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“…Acute kidney injury is described in just one of the cases. 5 Renal failure in donors is due to metabolic acidosis secondary to glycolate and calcium oxalate deposition and can occur 24 to 72 hours after consumption. 6 One concern when accepting the liver from such a donor is the possibility of EG still being present which could result in renal failure in the recipient.…”

Section: Discussionmentioning

confidence: 99%

“…Because this slows down the conversion of EG into its metabolites, it changes the half-life of EG to 19.7 hours. 5 This is important to take into account when working out when EG is fully cleared and whether the organ is safe to transplant. Hemodialysis of the donor also reduces the levels of EG and its metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…The liver appears to be less susceptible to oxalate deposits. 2 Table 1 updates the table in a previous publication 5 and summarizes all the reported cases to date. In all cases, liver enzymes were normal before removal of the liver and the liver biopsies showed no evidence of oxalate crystal deposits.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ethylene Glycol Poisoning Should Not Contraindicate Liver Donation

Burman

Watson

Kosmoliaptsis

2017

Transplantation Direct

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As the number of patients waiting to receive transplants increases, there is a need to explore all possible donation opportunities. In this case report, we describe the transplantation of a liver from a donor who died after ethylene glycol poisoning into a woman with alcoholic liver disease with cirrhosis and associated ascites. Donor management, including ethanol, fomepizol and haemodialysis, hastened clearance of ethylene glycol from the circulation, and after liver transplantation, the recipient exhibited no adverse effects suggestive of ethylene glycol toxicity, although recipient hepatic artery dissection and thrombosis necessitated retransplantation. Our experience suggests that donor death due to ethylene glycol intoxication should not contraindicate liver transplantation, particularly after appropriate donor management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%