Liver Damage after Transarterial Chemoembolization without Embolizing Agent in Unresectable Hepatocellular Carcinoma

Abstract

Transcatether arterial chemoembolization could represent an effective therapy against multifocal or advanced hepatocellular carcinoma, and its effectiveness is probably not decreased by using a modified procedure without embolizing agent (C-LIP). However, even when performing such a safe procedure, the hepatic functional reserve of the individual patient needs to be accurately evaluated in order to avoid liver failure.

Transarterial Chemoinfusion for Hepatocellular Carcinoma as Downstaging Therapy and a Bridge toward Liver Transplantation

“…TACI with maximally selective catheterization and highly concentrated chemotherapy preparations minimizes the risk of hepatocellular ischemic and cytotoxic complications and maximizes chemotherapy delivered to tumor tissue. TACI with superselective catheterization, although labor intensive, has been shown to have a safety profile superior to that of conventional TACE, allowing use of the technique in patients with borderline hepatic function who would not otherwise be able to tolerate TACE (12)(13)(14)(15).…”

Long‐term survival of patients with unresectable hepatocellular carcinoma treated with transcatheter arterial chemoinfusion

“…Theoretically, TACI without embolization in conjunction with maximum selectivity of catheterization minimizes the risk of hepatic ischemic and cytotoxic complications while maximizing delivery of chemotherapeutics to targeted tumour tissue. This method is the standard of care in many Asian countries, but only a few studies to date have examined the clinical outcomes of this technique 9–12 . The present study examines tumour response rates, survival rates and procedure‐related complication rates in a large cohort of consecutive patients with unresectable HCC treated with superselective TACI at a North American institution.…”

Construction of human single-chain variable fragment antibodies of medullary thyroid carcinoma and single photon emission computed tomography/computed tomography imaging in tumor-bearing nude mice

“…Monoclonal antibodies have increasingly become important in the diagnosis and treatment of tumors. Though a variety of anticancer drugs are available, their clinical application is limited due to their failure to distinguish cancer cells from normal cells, which cause toxic adverse effects (28,29). Monoclonal antibodies directly deliver the drug to the tumor, resulting in a high drug concentration in the tumor.…”