Liver Cancer Classification

Guido, Maria; Sarcognato, Samantha; Fassan, Matteo; Pizzi, Marco

doi:10.1007/978-3-319-15539-5_19

Cited by 1 publication

(1 citation statement)

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“…Liver cancer frequently arises as a result of liver cirrhosis and is linked to several etiologies, including chronic alcohol misuse, viral infections (hepatitis B and C), and metabolic syndrome. A tiny proportion of undifferentiated liver tumor cells known as liver cancer stem cells are essential for the development of cancer, metastasis, recurrence, and chemoresistance. − …”

Section: Utilizing the Ctdna In Cancer Diagnosis And Biomarkers In Va...mentioning

confidence: 99%

Recent Advancements in the Application of Circulating Tumor DNA as Biomarkers for Early Detection of Cancers

Mishra,

Ahmed,

Das

et al. 2024

ACS Biomater. Sci. Eng.

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Early detection of cancer is vital for increasing patient survivability chances. The three major techniques used to diagnose cancers are instrumental examination, tissue biopsy, and tumor biomarker detection. Circulating tumor DNA (ctDNA) has gained much attention in recent years due to advantages over traditional technology, such as high sensitivity, high specificity, and noninvasive nature. Through the mechanism of apoptosis, necrosis, and circulating exosome release in tumor cells, ctDNA can spread throughout the circulatory system and carry modifications such as methylations, mutations, gene rearrangements, and microsatellite instability. Traditional gene-detection technology struggles to achieve real-time, low-cost, and portable ctDNA measurement, whereas electrochemical biosensors offer low cost, high specificity alongside sensitivity, and portability for the detection of ctDNA. Therefore, this review focuses on describing the recent advancements in ctDNA biomarkers for various cancer types and biosensor developments for real-time, noninvasive, and rapid ctDNA detection. Further in the review, ctDNA sensors are also discussed in regards to their selections of probes for receptors based on the electrode surface recognition elements.

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Section: Utilizing the Ctdna In Cancer Diagnosis And Biomarkers In Va...mentioning

confidence: 99%