Liver

Larson, Martha M.

doi:10.1002/9781118840931.ch23

Cited by 1 publication

(2 citation statements)

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“…The International Agency for Research on Cancer (IARC) has predicted around 905 677 (4.7%) of new cases and 830 180 (8.3%) of death caused by liver cancer in 2020 from all around the globe. This shows that HCC is the fourth common cancer that leads to death globally for both men and women (8). In men, the areas of high incidence are Eastern Asia and Micronesia (8).…”

Section: Introductionmentioning

confidence: 97%

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Quantification of Absorbed Dose in 90y Selective Internal Radiation Therapy for Hepatocellular Carcinoma Treatment: A Review

Baharuddin,

Baharul Amin,

Anan

et al. 2023

JUMMEC

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Selective internal radiation therapy (SIRT) has emerged as a viable strategy for the treatment of incurable hepatic cancers. Although SIRT is a well-known therapy, continuous improvement in personalised dosimetry is required to improve the treatment planning and delivery of therapy. The ability to precisely foresee, plan, and administer the ideal dose to the tumour and non-tumoral tissues, including a final validation of the dose distribution, is the primary principle of radiation. The main way for safely personalised therapy for a maximum response while respecting normal tissue tolerances is to know the true absorbed dose to tissue compartments. Recent clinical studies highlighted the significance of personalised dosimetry to make it safer and more effective. Quantification of the absorbed dose distribution is of utmost importance in SIRT 90Y to optimise the hepatocellular carcinoma (HCC) treatment. The aim of this article was to review various dosimetric approaches in quantifying the absorbed dose of tumours and healthy liver tissue in 90Y SIRT. This article also compares the capabilities of organ-level dosimetry, voxel-level dosimetry and Monte Carlo simulation in assessing the absorbed dose in organs especially liver. The quantification of absorbed dose influences 90Y SIRT tumour dosimetry, while healthy liver absorbed dose values were comparable for all investigated imaging data. Personalised dosimetry for the tumour and healthy liver parenchyma after 90Y SIRT is recommended for patient-tailored therapy with enhanced therapeutic outcomes and for the safe administration of additional treatment cycles.

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Section: Introductionmentioning

confidence: 97%

“…This shows that HCC is the fourth common cancer that leads to death globally for both men and women (8). In men, the areas of high incidence are Eastern Asia and Micronesia (8). In women, the rates are generally much lower, the highest being in Northern Africa and Melanesia.…”

Section: Introductionmentioning

confidence: 99%