Liver and kidney foreign bodies granulomatosis in a patient with malocclusion, bruxism, and worn dental prostheses

Ballestri, Marco; Baraldi, A.; Gatti, Antonietta; Furci, Luciana; Bagni, Alberto; Loria, Paola; Rapanà, Renato; Carulli, Nicola; Albertazzi, A

doi:10.1053/gast.2001.29333

Cited by 53 publications

(36 citation statements)

References 11 publications

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“…271 A case study shows that the wear of dental bridges leads to the accumulation of wear nanoparticles in the liver and kidneys. 204 The most probable absorption pathway was assumed to be via intestinal absorption. 204 Scanning electron microscopy and energy-dispersive microanalytical techniques identified the chemical compositions of particles in the liver and kidney biopsies, as well as in the stool, to be the same as the porcelain from dental prostheses.…”

Section: Organs' Nanoparticle Uptakementioning

confidence: 99%

“…204 The most probable absorption pathway was assumed to be via intestinal absorption. 204 Scanning electron microscopy and energy-dispersive microanalytical techniques identified the chemical compositions of particles in the liver and kidney biopsies, as well as in the stool, to be the same as the porcelain from dental prostheses. The maximum size of particles found in the liver ͑20 m͒ was larger than in the kidneys ͑below 6 m͒, suggesting that particles are absorbed by intestinal mucosa, and translocate to the liver before reaching the circulatory system and kidneys.…”

Section: Organs' Nanoparticle Uptakementioning

confidence: 99%

“…270 Dental prosthesis debris internalized by intestinal absorption can lead to severe health conditions, including fever, enlarged spleen and liver, suppression of bile flow, and acute renal failure. 204 These symptoms appeared about a year after the application of dental porcelain bridges. After the removal of dental bridges, and subsequent treatment with steroids, the clinical symptoms declined.…”

Section: Adverse Health Effects Of Liver and Kidney Uptakementioning

confidence: 99%

“…272 Exogenous sources are particles from food ͑such as colorants, e.g., titanium oxide͒, pharmaceuticals, water, cosmetics ͑toothpaste and lipstick͒, 272 dental prosthesis debris, 204 and inhaled particles. 147 The dietary consumption of nanoparticles in developed countries is estimated around 10 12 particles/person per day.…”

Section: Exposure Sourcesmentioning

confidence: 99%

“…30 For example, rats with experimentally induced diabetes had a 100-fold increase in the absorption of 2 m polystyrene particles 30 relative to nondiabetic rats. Also inflammation may lead to the uptake and translocation of larger particles of up to 20 m. 204 The kinetics of particles in the gastrointestinal tract depends strongly on the charge of the particles, positively charged latex particles are trapped in the negatively charged mucus, while negatively charged latex nanoparticles diffused across the mucus layer and became available for interaction with epithelial cells. 30 …”

Section: Size and Charge Dependent Uptakementioning

confidence: 99%

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Nanomaterials and nanoparticles: Sources and toxicity

2007

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This review is presented as a common foundation for scientists interested in nanoparticles, their origin, activity, and biological toxicity. It is written with the goal of rationalizing and informing public health concerns related to this sometimes-strange new science of 'nano', while raising awareness of nanomaterials' toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and that our bodily systems are well adapted to protect us from these potentially harmful intruders. The reticuloendothelial system in particular actively neutralizes and eliminates foreign matter in the body, including viruses and non-biological particles. Particles originating from human activities have existed for millennia, e.g. smoke from combustion and lint from garments, but the recent development of industry and combustion-based engine transportation has profoundly increased anthropogenic particulate pollution. Significantly, technological advancement has also changed the character of particulate pollution, increasing the proportion of nanometer-sized particles -"nanoparticles" and expanding the variety of chemical compositions. Recent epidemiological studies have shown a strong correlation between particulate air pollution levels, respiratory and cardiovascular diseases, various cancers, and mortality. Adverse effects of nanoparticles on human health depend on individual factors such as genetics and existing disease, as well as exposure, and nanoparticle chemistry, size, shape, agglomeration state, and electromagnetic properties. Animal and human studies show that inhaled nanoparticles are less efficiently removed than larger particles by the macrophage clearance mechanisms in the lung, causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain. The key to understanding the toxicity of nanoparticles is that their minute size, smaller than cells and cellular organelles, allows them to penetrate these basic biological structures, disrupting their normal function. Examples of toxic effects include tissue inflammation, and altered cellular redox balance toward oxidation, causing abnormal function or cell death. The manipulation of matter at the scale of atoms, "nanotechnology", is creating many new materials with characteristics not always easily predicted from current knowledge. Within the near-limitless diversity of these materials, some happen to be toxic to biological systems, others are relatively benign, while others confer health benefits. Some of these materials have desirable characteristics for industrial applications, as nanostructured materials often exhibit beneficial properties, from UV absorbance in sunscreen to oil-less lubrication of motors. A rational science-based approach is needed to minimize harm caused by these materials, while supporting continued study and appropriate industrial develop...

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Section: Organs' Nanoparticle Uptakementioning

confidence: 99%

Section: Organs' Nanoparticle Uptakementioning

confidence: 99%

Section: Adverse Health Effects Of Liver and Kidney Uptakementioning

confidence: 99%

Section: Exposure Sourcesmentioning

confidence: 99%

Section: Size and Charge Dependent Uptakementioning

confidence: 99%

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Nanomaterials and nanoparticles: Sources and toxicity

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Metal Nanoparticle Health Risk Assessment

et al. 2009

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Engineered Nanomaterials

Misra

Tetley

Thorley

et al. 2011

Pollutants, Human Health and the Environment

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and Catalysis. He has been working in the environmental protection, multifunctional materials development, and analytical chemistry fields for 15 years and has a background of leading and managing large multidisciplinary, multi-partner research projects. He has been the author/co-author of more than 30 articles indexed in the Web of Science, Scopus, and other databases, 3 book chapters, and more than 60 participations in national and international scientific conferences. He has also filed 4 patents regarding materials development for ecofriendly processes.

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Liver and kidney foreign bodies granulomatosis in a patient with malocclusion, bruxism, and worn dental prostheses

Cited by 53 publications

References 11 publications

Nanomaterials and nanoparticles: Sources and toxicity

Nanomaterials and nanoparticles: Sources and toxicity

Metal Nanoparticle Health Risk Assessment

Engineered Nanomaterials

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