Liver abscess in children: an overview

Mishra, Kirtisudha; Basu, Srikanta; Roychoudhury, Subhasis; Kumar, Praveen

doi:10.1007/s12519-010-0220-1

Cited by 93 publications

(167 citation statements)

References 43 publications

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“…Clinically, S. aureus is a relatively common cause of liver abscesses (32,33). Thus, a particularly interesting observation from this study is that the in vivo survival defect for USA300 fakA-and essB-mutant strains is much stronger in the liver than in the kidneys in the i.v.…”

Section: Discussionmentioning

confidence: 72%

Host-derived fatty acids activate type VII secretion in Staphylococcus aureus

Lopez¹,

Tan²,

Yan³

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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The type VII secretion system (T7SS) of Staphylococcus aureus is a multiprotein complex dedicated to the export of several virulence factors during host infection. This virulence pathway plays a key role in promoting bacterial survival and the long-term persistence of staphylococcal abscess communities. The expression of the T7SS is activated by bacterial interaction with host tissues including blood serum, nasal secretions, and pulmonary surfactant. In this work we identify the major stimulatory factors as host-specific cisunsaturated fatty acids. Increased T7SS expression requires host fatty acid incorporation into bacterial biosynthetic pathways by the S. aureus fatty acid kinase (FAK) complex, and FakA is required for virulence. The incorporated cis-unsaturated fatty acids decrease S. aureus membrane fluidity, and these altered membrane dynamics are partially responsible for T7SS activation. These data define a molecular mechanism by which S. aureus cells sense the host environment and implement appropriate virulence pathways.type VII secretion | Staphylococcus aureus | fatty acids | virulence

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Section: Discussionmentioning

confidence: 72%

Host-derived fatty acids activate type VII secretion in Staphylococcus aureus

Lopez¹,

Tan²,

Yan³

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…La epidemiología en nuestro estudio mostró como patógeno predominante a S. aureus, similar a lo publicado tanto en países desarrollados como en Espíritu Santo, Brasil 6,9 . Yu-Lung Hsu publicó que, K. pneumoniae y Streptococcus spp.…”

Section: Experiencia Clínicaunclassified

“…Coincidiendo con la literatura especializada, S. aureus fue el patógeno más frecuente, predominando en niños con infección de piel y tejidos blandos o respiratoria asociada 9,11,12 .…”

Section: Experiencia Clínicaunclassified

Absceso hepático piógeno en pediatría: experiencia en un centro pediátrico de referencia

Carballo¹,

Cazes²,

Matsuda³

et al. 2017

Rev. chil. infectol.

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“…1 A liver abscess is twice as common in the right lobe than in the left lobe of the liver. 2 The annual incidence of liver abscess in children varies widely in different regions of the world, occurring more commonly in developing countries. 2 The incidence ranges from 28 per 100 000 in South African children, to more than 79 per 100 000 paediatric admissions in India.…”

Section: Introductionmentioning

confidence: 99%

“…2 The annual incidence of liver abscess in children varies widely in different regions of the world, occurring more commonly in developing countries. 2 The incidence ranges from 28 per 100 000 in South African children, to more than 79 per 100 000 paediatric admissions in India. 3,4 Risk factors for liver abscesses in children include malnutrition, sickle cell disease, acquired immunodeficiency syndrome and congenital immunodeficiencies, such as chronic granulomatous disease.…”

Section: Introductionmentioning

confidence: 99%