Liver

doi:10.1016/b978-1-4160-3661-6.00061-4

Cited by 4 publications

(1 citation statement)

References 521 publications

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“…NPCs include endothelial cells (~50%), Kupffer cells (resident macrophages, ~20%), lymphocytes (~25%), cholangiocytes (~5%) and hepatic stellate cells (less than 1%) (Racanelli and Rehermann 2006). Hepatocytes contribute to a wide range of metabolic activity including xenobiotic metabolism (Washabau et al 2012). Since hepatocytes are in charge of the major clearance work of DL PCBs, their responses have been extensively investigated (Zhang et al 2012;Mesnage et al 2018;Chen et al 2020b).…”

Section: Introductionmentioning

confidence: 99%

Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure

Yang³

et al. 2023

Preprint

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Polychlorinated biphenyls (PCBs) are ubiquitous and representative pollutants that pose great health risks. While cells' responses to dioxin-like PCBs tend to be studied on a bulk scale, few studies have been made from a single-cell level. Here, by using single-cell RNA sequencing, we depicted a detailed landscape of hepatic nonparenchymal cells' intricate responses to PCB126 exposure. A total of 13 clusters were identified. Notably, PCB126 exposure resulted in cell-type-specific gene expression profiles and genetic pathways. By analyzing genes related to aryl hydrocarbon receptors, we discovered that PCB126 induced the canonical genomic AhR pathway mainly in endothelial cells. In contrast, other cell types showed little induction. Enrichment pathway analysis indicated that immune cells changed their transcriptional patterns in response to PCB126. ScRNA-seq is a powerful tool to dissect underlying mechanisms of chemical toxicity regarding biological heterogeneity. Taken together, our study not only extends our current understanding of PCB126 toxicity, but also emphasizes the importance of in vivo cell heterogeneity in environmental toxicology.

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Section: Introductionmentioning

confidence: 99%

Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure

Yang³

et al. 2023

Preprint

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Clonal Blumea lacera (Burm. f.) DC. ameliorates diabetic conditions by modulating carbohydrate and lipid hydrolases: a combine in vivo experimental and chemico-biological interaction study

Hasan¹,

Islam

Raihan

et al. 2023

3 Biotech

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MRI findings in two West Highland White Terrier dogs with hepatic encephalopathy secondary to portosystemic shunt

Fernandes¹,

Driver²,

Rose³

et al. 2019

Vet Record Case Reports

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A portosystemic shunt is an abnormal communication between the portal vascular system and the systemic circulation. A significant number of clinical signs associated with portosystemic shunting result from hepatic encephalopathy (HE); a syndrome encompassing neurological signs such as including changes in behaviour, ataxia, unresponsiveness, pacing, circling, blindness, seizures, coma and death. We present two West Highland White Terrier dogs diagnosed with HE based on clinical signs, bile acid stimulation test and imaging of the abnormal vessel communicating the portal and the systemic circulation. Magnetic resonance sequences of the brain revealed a poorly marginated and diffuse, bilateral and symmetric hyperintense lesions on T2-weighted, fluid attenuation inversion recovery and diffusion-weighted sequences relative to the brain parenchyma including the medial longitudinal fasciculus and reticular formation in the brainstem. No abnormalities were detected on T1-weighted sequences.

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Liver

Cited by 4 publications

References 521 publications

Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure

Single-cell transcriptomic analysis of mouse liver reveals nonparenchymal cells’ intricate responses to PCB126 exposure

Clonal Blumea lacera (Burm. f.) DC. ameliorates diabetic conditions by modulating carbohydrate and lipid hydrolases: a combine in vivo experimental and chemico-biological interaction study

MRI findings in two West Highland White Terrier dogs with hepatic encephalopathy secondary to portosystemic shunt

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