Livebirth after uterus transplantation

Abstract

Jane and Dan Olsson Foundation for Science.

Uterus Transplant: Does It Have Legs?

“…Among these the first successful childbirth was in September 2014 in a 35-yearold patient with uterine agenesis who had received the uterus from a 61-year-old postmenopausal patient of 7 years [14]. Two more patients from the same group gave birth in November 2014.…”

Uterus transplant: Are we close to this reality?

“…12 More recently, in 2014, the first birth of a series of nine patients undergoing uterine transplantation occurred in Sweden. 13 Some researchers believe that this event was a milestone in reproductive medicine, allowing pregnancy in a woman aged 35 years with congenital uterine agenesis (MRKH syndrome) who received the uterus from a 61-year-old donor that became menopausal seven years earlier. 13 Subsequently, three more births were successfully described, and others may result from this series of cases.…”

“…13 Some researchers believe that this event was a milestone in reproductive medicine, allowing pregnancy in a woman aged 35 years with congenital uterine agenesis (MRKH syndrome) who received the uterus from a 61-year-old donor that became menopausal seven years earlier. 13 Subsequently, three more births were successfully described, and others may result from this series of cases. [14][15][16] Therefore, a new frontier is opening up with these reports in the field of human reproduction.…”

“…It is noted that the development of this technique was possible only after great efforts in the field of microsurgical techniques; extensive training in animal models; research developed with transplantation of other organs; and advances in human reproduction, such as embryo cryopreservation and embryo biopsy; as well as the enhancement of drugs to prevent rejection of the uterus. [13][14][15][16][17][18][19] The evolution of immunosuppressants greatly diminished the fear of teratogenicity and raised the expectation of success, especially after the reports of the Swedish group. 13 However, training in other centers is necessary both regarding the technical aspect of transplants and management of immunosuppressive therapy.…”

“…[13][14][15][16][17][18][19] The evolution of immunosuppressants greatly diminished the fear of teratogenicity and raised the expectation of success, especially after the reports of the Swedish group. 13 However, training in other centers is necessary both regarding the technical aspect of transplants and management of immunosuppressive therapy. 18,19 We all know that there are still major challenges for the improvement of the technique, selection of potential donors, and the preservation of the organ to be transplanted.…”