Live performance and processing yields of broilers fed diets with tiamulin and salinomycin combinations

Vieira, S. L.; Favero, A.; Berres, Josemar; Freitas, Dimitri Moreira de; Martínez, JA; Mayorga, Meri; Coneglian, Jorge Luis Bernardon

doi:10.1590/s1516-635x2010000100005

Cited by 3 publications

(2 citation statements)

References 12 publications

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“…Benefits of the inclusion of AGP in broiler diets on live performance have long been demonstrated (Miles et al, 2006;Cervantes et al, 2008;Hossain et al, 2008;Demir et al, 2008;Vieira et al, 2010). The mechanism of action of these compounds, however, is not easily explained.…”

Section: Resultsmentioning

confidence: 99%

Reassessing flavophospholipol effects on broiler performance

et al. 2012

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-The objective of this study was to evaluate bird responses to flavophospholipol at higher doses than those recommended by the Brazilian legislation. A trial was conducted with 900 male broilers divided into five doses of flavophospholipol: 0, 2, 4, 8 and 16 mg/kg. The performance evaluation was conducted weekly until 42 days of age. The evaluated parameters were: weight gain, feed conversion corrected for mortality, feed intake and mortality. At the end of experimental period, birds supplemented with growth promoter differed from the negative control for weight gain and feed conversion in the period from 1 to 42 days. Body weight gain and feed conversion were significantly higher for birds fed 16 mg/kg of flavophospholipol, compared with treatment without the growth promoter in the period from 1 to 21 days. In the accumulated period from 22 to 42 days, all doses were different for the negative control for feed conversion and body weight gain. The performance improvement was maximized at the dosage of 10.1 mg/kg for feed conversion ratio and 10.9 mg/kg for body weight gain by regression analysis. Flavomycin can be used as a growth promoter to improve feed conversion ratio and body weight gain in broilers from 1 to 42 days of age.

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Section: Resultsmentioning

confidence: 99%

Reassessing flavophospholipol effects on broiler performance

et al. 2012

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“…Furthermore, Vieira et al showed that the administration of tiamulin (30, 20, and 15 ppm) with salinomycin did not adversely affect broiler performance at 1–21 and 22–42 days. It was also observed that tiamulin improved feed conversion in broiler chickens [ 83 ].…”

Section: Interaction Of Tiamulin With Ionophoresmentioning

confidence: 99%

Ionophore Toxicity in Animals: A Review of Clinical and Molecular Aspects

Ekinci

Chłodowska

Olejnik

2023

IJMS

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For many years, ionophores have been used to control coccidiosis in poultry. However, misuse of ionophores can cause toxicity with significant clinical symptoms. The most critical factors influencing ionophores’ toxicity are administration dose, species, and animal age. Although clinical signs of ionophore intoxication are well studied, the toxicity mechanisms of the ionophores at the molecular level still are not fully elucidated. This review summarizes the studies focused on polyether ionophores toxicity mechanisms in animals at the clinical and molecular levels. Studies show that ionophore toxicity mainly affects myocardial and skeletal muscle cells. The molecular mechanism of the toxication could be explained by the inhibition of oxidative phosphorylation via dysregulation of ion concentration. Tiamulin-ionophore interaction and the synergetic effect of tiamulin in ionophore biotransformation are discussed. Furthermore, in recent years ionophores were candidates for reprofiling as antibacterial and anti-cancer drugs. Identifying ionophores’ toxicity mechanisms at the cellular level will likely help develop novel therapies in veterinary and human medicine.

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Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 8: Pleuromutilins: tiamulin and valnemulin

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

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The specific concentrations of tiamulin and valnemulin in non-target feed for food-producing animals, below which there would not be an effect on the emergence of, and/or selection for, resistance in bacteria relevant for human and animal health, as well as the specific antimicrobial concentrations in feed which have an effect in terms of growth promotion/increased yield were assessed by EFSA in collaboration with EMA. Details of the methodology used for this assessment, associated data gaps and uncertainties, are presented in a separate document. To address antimicrobial resistance, the Feed Antimicrobial Resistance Selection Concentration (FARSC) model developed specifically for the assessment was applied. However, due to the lack of data on the parameters required to calculate the FARSC, it was not possible to conclude the assessment until further experimental data become available. To address growth promotion, data from scientific publications obtained from an extensive literature review were used. Levels in feed that showed to have an effect on growth promotion/ increased yield were reported for tiamulin, while for valnemulin no suitable data for the assessment were available. It was recommended to carry out studies to generate the data that are required to fill the gaps which prevented the calculation of the FARSC for these two antimicrobials.

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Live performance and processing yields of broilers fed diets with tiamulin and salinomycin combinations

Cited by 3 publications

References 12 publications

Reassessing flavophospholipol effects on broiler performance

Reassessing flavophospholipol effects on broiler performance

Ionophore Toxicity in Animals: A Review of Clinical and Molecular Aspects

Maximum levels of cross‐contamination for 24 antimicrobial active substances in non‐target feed. Part 8: Pleuromutilins: tiamulin and valnemulin

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