Live<i>Clostridia</i>: A Powerful Tool in Tumor Biotherapy

Mellaert, Lieve Van; Wei, Ming Q.; Anné, Jozef

doi:10.1002/9780470626528.ch4

Cited by 2 publications

(1 citation statement)

References 54 publications

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“…Other attenuated bacteria have been used to promote the up-regulation of the immune system such as Clostridium, Salmonella, Bifidobacteria and Listeria (Fu et al 2010;Hoffman 2010;Mellaert et al 2010;Rothman et al 2010). C. novyi-NT spores potentiate an inflammatory response in the tumor microenvironment resulting in enhanced cytokine production such as IL-6, MIP-2, G-CSF and TIMP-1 (Xu et al 2009).…”

Section: Up-regulation Of the Immune Systemmentioning

confidence: 99%

Engineering of bacterial strains and their products for cancer therapy

Bernardes

Chakrabarty

Fialho

2013

Appl Microbiol Biotechnol

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The use of live bacteria in cancer therapies offers exciting possibilities. Nowadays, an increasing number of genetically engineered bacteria are emerging in the field, with applications both in therapy and diagnosis. In parallel, purified bacterial products are also gaining relevance as new classes of bioactive products to treat and prevent cancer growth and metastasis. In the first part of the article, we review the latest findings regarding the use of live bacteria and products as anti-cancer agents, paying special attention to immunotoxins, proteins, and peptides. In particular, we focus on the recent results of using azurin or its derived peptide as anticancer therapeutic agents. In the second part, we discuss the challenges of using metagenomic techniques as a distinctive approach for discovering new anti-cancer agents from bacterial origin.

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Section: Up-regulation Of the Immune Systemmentioning

confidence: 99%

Engineering of bacterial strains and their products for cancer therapy

Bernardes

Chakrabarty

Fialho

2013

Appl Microbiol Biotechnol

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Dysbiosis of skin microbiome and gut microbiome in melanoma progression

et al. 2022

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Background The microbiome alterations are associated with cancer growth and may influence the immune system and response to therapy. Particularly, the gut microbiome has been recently shown to modulate response to melanoma immunotherapy. However, the role of the skin microbiome has not been well explored in the skin tumour microenvironment and the link between the gut microbiome and skin microbiome has not been investigated in melanoma progression. Therefore, the aim of the present study was to examine associations between dysbiosis in the skin and gut microbiome and the melanoma growth using MeLiM porcine model of melanoma progression and spontaneous regression. Results Parallel analysis of cutaneous microbiota and faecal microbiota of the same individuals was performed in 8 to 12 weeks old MeLiM piglets. The bacterial composition of samples was analysed by high throughput sequencing of the V4-V5 region of the 16S rRNA gene. A significant difference in microbiome diversity and richness between melanoma tissue and healthy skin and between the faecal microbiome of MeLiM piglets and control piglets were observed. Both Principal Coordinate Analysis and Non-metric multidimensional scaling revealed dissimilarities between different bacterial communities. Linear discriminant analysis effect size at the genus level determined different potential biomarkers in multiple bacterial communities. Lactobacillus, Clostridium sensu stricto 1 and Corynebacterium 1 were the most discriminately higher genera in the healthy skin microbiome, while Fusobacterium, Trueperella, Staphylococcus, Streptococcus and Bacteroides were discriminately abundant in melanoma tissue microbiome. Bacteroides, Fusobacterium and Escherichia-Shigella were associated with the faecal microbiota of MeLiM piglets. Potential functional pathways analysis based on the KEGG database indicated significant differences in the predicted profile metabolisms between the healthy skin microbiome and melanoma tissue microbiome. The faecal microbiome of MeLiM piglets was enriched by genes related to membrane transports pathways allowing for the increase of intestinal permeability and alteration of the intestinal mucosal barrier. Conclusion The associations between melanoma progression and dysbiosis in the skin microbiome as well as dysbiosis in the gut microbiome were identified. Results provide promising information for further studies on the local skin and gut microbiome involvement in melanoma progression and may support the development of new therapeutic approaches.

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LiveClostridia: A Powerful Tool in Tumor Biotherapy

Cited by 2 publications

References 54 publications

Engineering of bacterial strains and their products for cancer therapy

Engineering of bacterial strains and their products for cancer therapy

Dysbiosis of skin microbiome and gut microbiome in melanoma progression

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