Live E. coli bacteria label-free sensing using a microcavity in-line Mach-Zehnder interferometer

Janik, Monika; Koba, Marcin; Celebańska, Anna; Bock, Wojtek J.; Śmietana, Mateusz

doi:10.1038/s41598-018-35647-2

Cited by 46 publications

(26 citation statements)

References 35 publications

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“…In general, we observe here a shift of the transmission minima towards shorter wavelengths with increasing RI values in the cavity. The substantiation of the spectrum evolution was presented in our previous work [27]. It is worth mentioning that due to the micromachined interferometric structure, the overall transmission dropped by ca.…”

Section: Ri Sensing With Lpg or µMzi Structuresupporting

confidence: 75%

Combined Long-Period Fiber Grating and Microcavity In-Line Mach–Zehnder Interferometer for Refractive Index Measurements with Limited Cross-Sensitivity

Janik

Koba

Król

et al. 2020

Sensors

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This work discusses sensing properties of a long-period grating (LPG) and microcavity in-line Mach–Zehnder interferometer (µIMZI) when both are induced in the same single-mode optical fiber. LPGs were either etched or nanocoated with aluminum oxide (Al2O3) to increase its refractive index (RI) sensitivity up to ≈2000 and 9000 nm/RIU, respectively. The µIMZI was machined using a femtosecond laser as a cylindrical cavity (d = 60 μm) in the center of the LPG. In transmission measurements for various RI in the cavity and around the LPG we observed two effects coming from the two independently working sensors. This dual operation had no significant impact on either of the devices in terms of their functional properties, especially in a lower RI range. Moreover, due to the properties of combined sensors two major effects can be distinguished—sensitivity to the RI of the volume and sensitivity to the RI at the surface. Considering also the negligible temperature sensitivity of the µIMZI, it makes the combination of LPG and µIMZI sensors a promising approach to limit cross-sensitivity or tackle simultaneous measurements of multiple effects with high efficiency and reliability.

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Section: Ri Sensing With Lpg or µMzi Structuresupporting

confidence: 75%

Combined Long-Period Fiber Grating and Microcavity In-Line Mach–Zehnder Interferometer for Refractive Index Measurements with Limited Cross-Sensitivity

Janik

Koba

Król

et al. 2020

Sensors

Self Cite

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“…This added phase causes a change of intensity in the interference signal and provides species-specific optical detection in a low-cost MZI biosensor. Janik et al built an MZI directly into an optical fiber by machining a small cavity through the cladding and core [185]. This cavity was functionalized with bacterial phages to immobilize free-floating bacteria.…”

Section: Interferencementioning

confidence: 99%

“…Here, Sl is the length of the sensor area, L is the length of the sensor arm, d is the distance between the sensor and reference arms, and θ is the opening angle of the Y-divisor for angular Y-junctions, whereas R is the radius of curvature of the Y-divisor for S-bend Y-junctions. Reproduced with permission from [185]. Copyright © 2020, published by Springer Nature.…”

Section: Molecules 2020 25 X 17 Of 32mentioning

confidence: 99%

Advances in Optical Detection of Human-Associated Pathogenic Bacteria

2020

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Bacterial infection is a global burden that results in numerous hospital visits and deaths annually. The rise of multi-drug resistant bacteria has dramatically increased this burden. Therefore, there is a clinical need to detect and identify bacteria rapidly and accurately in their native state or a culture-free environment. Current diagnostic techniques lack speed and effectiveness in detecting bacteria that are culture-negative, as well as options for in vivo detection. The optical detection of bacteria offers the potential to overcome these obstacles by providing various platforms that can detect bacteria rapidly, with minimum sample preparation, and, in some cases, culture-free directly from patient fluids or even in vivo. These modalities include infrared, Raman, and fluorescence spectroscopy, along with optical coherence tomography, interference, polarization, and laser speckle. However, these techniques are not without their own set of limitations. This review summarizes the strengths and weaknesses of utilizing each of these optical tools for rapid bacteria detection and identification.

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“…From a practical point of view, a limitation of the optical waveguide-based approach is the need to launch light into the waveguide, which requires rather demanding coupling arrangements and makes these devices not compatible with standard microscopes. As an alternative, the interferometer can be realized in an optical fibre, for which standardized coupling interfaces exist [70,71]. The interferometer can be made of two identical chirped long period gratings (CLPGs) as illustrated in Figure 2(c).…”

Section: Optical Waveguides and Interferometric Approachesmentioning

confidence: 99%

Nanophotonics for bacterial detection and antimicrobial susceptibility testing

2020

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Photonic biosensors are a major topic of research that continues to make exciting advances. Technology has now improved sufficiently for photonics to enter the realm of microbiology and to allow for the detection of individual bacteria. Here, we discuss the different nanophotonic modalities used in this context and highlight the opportunities they offer for studying bacteria. We critically review examples from the recent literature, starting with an overview of photonic devices for the detection of bacteria, followed by a specific analysis of photonic antimicrobial susceptibility tests. We show that the intrinsic advantage of matching the optical probed volume to that of a single, or a few, bacterial cell, affords improved sensitivity while providing additional insight into single-cell properties. We illustrate our argument by comparing traditional culture-based methods, which we term macroscopic, to microscopic free-space optics and nanoscopic guided-wave optics techniques. Particular attention is devoted to this last class by discussing structures such as photonic crystal cavities, plasmonic nanostructures and interferometric configurations. These structures and associated measurement modalities are assessed in terms of limit of detection, response time and ease of implementation. Existing challenges and issues yet to be addressed will be examined and critically discussed.

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Live E. coli bacteria label-free sensing using a microcavity in-line Mach-Zehnder interferometer

Cited by 46 publications

References 35 publications

Combined Long-Period Fiber Grating and Microcavity In-Line Mach–Zehnder Interferometer for Refractive Index Measurements with Limited Cross-Sensitivity

Combined Long-Period Fiber Grating and Microcavity In-Line Mach–Zehnder Interferometer for Refractive Index Measurements with Limited Cross-Sensitivity

Advances in Optical Detection of Human-Associated Pathogenic Bacteria

Nanophotonics for bacterial detection and antimicrobial susceptibility testing

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