Live birth rate with repeat microdissection TESE and intracytoplasmic sperm injection after a conventional testicular biopsy in men with nonobstructive azoospermia

Isotretinoin for the treatment of nonobstructive azoospermia

“…It is also possible that the successful repeat micro-TESE and live birth described in our report was unrelated to isotretinoin treatment. While the success of repeat micro-TESE in men with a prior successful micro-TESE is known to be above 80%, 11 12 the success of repeat micro-TESE after prior unsuccessful procedure appears to be very low, with one series reporting a single live birth in thirty-nine attempts (3%), 12 although this success rate may vary with the skill of the surgeon, and the first surgeon may have been unable to find sperm that were present. However, it must be noted that spermatogenesis was readily apparent on the second (postisotretinoin) TESE ( Figure 1 ).…”

Surgically acquired sperm use for assisted reproductive technology: trends and perinatal outcomes, USA, 2004–2015

“…Results were similar among cycles with a sole diagnosis of male factor infertility, and for the subset of such cycles in which the female partner was under 35 years old. While prior studies have investigated cycle level outcomes such as fertilization rate, implantation rate, and pregnancy rate for surgically acquired sperm used in IVF cycles [9][10][11][12][13][14][15][16][17][18][19][20][21], this is one of the first studies to use national US ART data to explore perinatal outcomes including miscarriage, term delivery, and normal birth weight delivery. Several prior studies with smaller sample sizes also showed similar neonatal outcomes between infants conceived using either testicular or ejaculated sperm [23][24][25][26].…”

“…To our knowledge, only a few single-center studies have been published detailing the outcomes among cycles using surgically acquired sperm [2][3][4][5][6], particularly in comparison to those using ejaculated sperm [7,8], among men with male factor infertility. Some of these studies specifically investigated outcomes among cycles for which sperm was acquired from either the epididymis [9][10][11][12] or the testes [10,[13][14][15][16][17][18][19][20], but were limited by small sample size. Additionally, prior studies using national data focused primarily on IVF cycle outcomes rather than perinatal outcomes [21].…”

A clinical trial on the consistency of bilateral testicular tissue histopathology and Johnsen score: single side or bilateral side biopsy?

“…Conventional TESE, combined with micro-TESE, can be used in selected patients with atrophic testes [ 12 ]. Another paper showed that testicular motile sperm were successfully retrieved in 82.9% of NOA men who had sperm detected in a previous biopsy (cTESE), and in15.3% of NOA men with no sperm in aprevious biopsy ( p <0.01) [ 19 ].…”