Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience

Chai, Joyce; Yeung, Tracy WY; Lee, Vivian CY; Li, Raymond HW; Lau, Esther Yuet Ying; Yeung, William S.B.; Ho, PC; Ng, Ernest H.Y.

doi:10.12809/hkmj134065

Cited by 9 publications

(12 citation statements)

References 22 publications

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“…Rate of implantation, cumulative pregnancy rates per transfer, and cumulative live birth delivery were similar among both groups. Similar results were obtained in other settings [ 71 , 72 ]. In a recent Cochrane review [ 73 ], the policy of single embryo transfer versus two embryo transfer was evaluated regarding pregnancy rates.…”

Section: Methodssupporting

confidence: 90%

Infertility care and the introduction of new reproductive technologies in poor resource settings

Bahamondes

Makuch

2014

Reprod Biol Endocrinol

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BackgroundThe overall prevalence of infertility was estimated to be 3.5–16.7% in developing countries and 6.9–9.3% in developed countries. Furthermore, according to reports from some regions of sub-Saharan Africa, the prevalence rate is 30–40%. The consequences of infertility and how it affects the lives of women in poor-resource settings, particularly in developing countries, has become an important issue to be discussed in reproductive health. In some societies, the inability to fulfill the desire to have children makes life difficult for the infertile couple. In many regions, infertility is considered a tragedy that affects not only the infertile couple or woman, but the entire family.MethodsThis is a position paper which encompasses a review of the needs of low-income infertile couples, mainly those living in developing countries, regarding access to infertility care, including ART and initiatives to provide ART at low or affordable cost. Information was gathered from the databases MEDLINE, CENTRAL, POPLINE, EMBASE, LILACS, and ICTRP with the key words: infertility, low income, assisted reproductive technologies, affordable cost, low cost.ResultsThere are few initiatives geared toward implementing ART procedures at low cost or at least at affordable cost in low-income populations. Nevertheless, from recent studies, possibilities have emerged for new low-cost initiatives that can help millions of couples to achieve the desire of having a biological child.ConclusionsIt is necessary for healthcare professionals and policymakers to take into account these new initiatives in order to implement ART in resource-constrained settings.

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Section: Methodssupporting

confidence: 90%

Infertility care and the introduction of new reproductive technologies in poor resource settings

Bahamondes

Makuch

2014

Reprod Biol Endocrinol

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“…This is a very reassuring result that should be taken into consideration, when performing AR Technologies in this group of patients, to avoid multiple gestations and their undesired consequences. Similar results have already been published for this age group (Koryntová et al, 2005;Yang et al, 2012;Chai et al, 2014). The present study divided patients into four age groups as recent reports have been using this system when describing women´s fertility status (Morin et al, 2014).…”

Section: Discussionsupporting

confidence: 74%

The impact of age on blastocyst scoring after single and double embryo transfers

Bös-Mikich

Michels

Dutra

et al. 2016

JBRA Assisted Reproduction

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Objective: The aim of the present study was to assess the putative relationship between patient's age and blastocyst scores, in single (SET) or double (DET) transfer cycles, that resulted in single or twin pregnancy or non-pregnancy. Second, we analyzed the effect of maternal age on clinical gestation and implantation rates after single and double blastocyst transfers. Methods: Retrospective analysis of 164 assisted reproduction cycles with embryo transfers. Results: Data demonstrated that for both, young (<35 years of age) and older (≥35 years of age) women, trophectoderm (TE) score is the most important parameter to assess concerning embryo selection. However, inner cell mass (ICM) also plays an important role on blastocyst selection in the group of older patients. In addition, our data shows that for young women the transfer of a single blastocyst results in similar gestational rates as those for DET. Conclusion: We suggest that blastocyst grading for patients aged 35 years or above shall be performed using a strict grading policy, possibly not of a single parameter, but TE, ICM and expansion grades together, to choose the "best combined-score blastocyst". DETs should be considered, particularly after previous cycles with pregnancy failures.

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“…Previous studies showed that multiple pregnancy rates were increased with DET [5,6,23,24]. Interestingly, Li et al reported a higher multiple pregnancy rate in DET with two good quality embryos when compared with DET with one good and one poor quality embryo, and related this finding with the higher implantation rate of good quality embryos.…”

Section: Group a (Det Withmentioning

confidence: 94%

Impact of Transferring a Poor Quality Embryo Along with a Good Quality Embryo on Pregnancy Outcomes in IVF/ICSI Cycles: a Retrospective Study

Aldemir

Özelçi

Başer

et al. 2020

Geburtshilfe Frauenheilkd

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Background The number and the quality of embryos transferred are important predictors of success in in vitro fertilization (IVF) cycles. In the presence of more than one good quality embryo on the transfer day, double-embryo transfer (DET) can be performed with these embryos, but generally, different quality embryos are present in the available transfer cohort. We aimed to investigate the effect of transferring a poor quality embryo along with a good quality embryo on IVF outcomes. Methods In this study, 2298 fresh IVF/intracytoplasmic sperm injection (ICSI) cycles with two good quality embryos (group A), one good and one poor quality embryo (group B), and single good quality embryo (group C) transfers were examined. All groups were divided into two subgroups according to the transfer day as cleavage or blastocyst stage. Clinical pregnancy and live birth rates were the primary outcomes. Results In the cleavage stage transfer subgroups, the clinical pregnancy rates were lower in the single-embryo transfer (SET) subgroup compared with DET subgroups, but the difference was not statistically significant compared with DET with mixed quality embryos. The live birth rates were comparable between the three groups. In the blastocyst transfer subgroups, the clinical pregnancy and live birth rates were significantly higher in DET with two good quality embryos than DET with mixed quality embryos and SET groups. Multiple pregnancy rates were higher in both DET groups in terms of transfer day (p = 0.001). Conclusion DET with mixed quality embryos results with lower clinical pregnancy and live birth rates compared with DET with two good quality embryos at the blastocyst stage. At cleavage stage transfer, there is no difference in live birth rates between the two groups.

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Live birth rate, multiple pregnancy rate, and obstetric outcomes of elective single and double embryo transfers: Hong Kong experience

Cited by 9 publications

References 22 publications

Infertility care and the introduction of new reproductive technologies in poor resource settings

Infertility care and the introduction of new reproductive technologies in poor resource settings

The impact of age on blastocyst scoring after single and double embryo transfers

Impact of Transferring a Poor Quality Embryo Along with a Good Quality Embryo on Pregnancy Outcomes in IVF/ICSI Cycles: a Retrospective Study

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