Live-Birth Rate Associated With Repeat In Vitro Fertilization Treatment Cycles

Smith, Andrew; Tilling, Kate; Nelson, Scott M.; Lawlor, Debbie A.

doi:10.1001/jama.2015.17296

Cited by 171 publications

(151 citation statements)

References 30 publications

(50 reference statements)

Supporting

Mentioning

139

Contrasting

Unclassified

Order By: Relevance

“…Previous studies (23,24) also support our finding that the cumulative live birth rate increased after three or four IVF cycles, reinforcing the efficacy of extending treatment beyond three or four IVF cycles. We believe that this is also applies to women with symptomatic endometriosis who have failed several IVF treatments.…”

Section: Discussionsupporting

confidence: 87%

Fertility outcome of laparoscopic treatment in patients with severe endometriosis and repeated in vitro fertilization failures

Soriano

Adler

Bouaziz

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 87%

Fertility outcome of laparoscopic treatment in patients with severe endometriosis and repeated in vitro fertilization failures

Soriano

Adler

Bouaziz

et al. 2016

Fertility and Sterility

View full text Add to dashboard Cite

“…If one has 2 embryos, and the choice is to transfer 2 in 1 cycle, or 1 each in 2 cycles, data have shown that the overall pregnancy rate is actually higher with 2 in 1 cycle [126][127][128] . There is the potential for DCDA twins and rarely dichorionic-triamniotic triplets.…”

Section: Discussionmentioning

confidence: 99%

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Dziadosz

Evans²

2017

Fetal Diagn Ther

View full text Add to dashboard Cite

Background/Objectives: Multiple pregnancies have tripled in the United States over the past 3 decades. Attributed to increasing maternal age at delivery but more so assisted reproductive technological advances, an effort has been made to decrease twinning through elective single embryo transfer. We sought to review and evaluate risks of monochorionic twinning as a predictable consequence of increasing utilization of elective single embryo transfer on perinatal outcomes. Primary outcomes included twinning rates, fetal anomalies, growth, preterm birth, and mortality. Secondary outcomes included neurological and pulmonary disability, intrauterine growth restriction, and congenital cardiac anomalies and twin-twin transfusion syndrome. Data sources: PubMed and Embase. Results: A total of 106 studies identified by systematic search met the inclusion criteria. The trend for lower numbers of embryos transferred has inadvertently led to an increase in monochorionic twinning. This is associated with worse outcomes compared to dichorionic twinning and singleton gestations for all outcomes studied. Discussion: Of great concern for monochorionic twins is the risk profile of significant morbidity and mortality. Transfer of 2 embryos should be considered to avoid higher risks inherent to the shared placental phenomena related to monochorionic twins.

show abstract

“…6 However, cumulative livebirth rates are often reported either as one overall average rate or stratified by the woman's age or type of infertility at a national or IVF clinic level. [7][8][9][10][11] Given that many other patient and treatment characteristics can affect the success of IVF or ICSI, 12 it can be difficult for clinicians to counsel couples as to their individualised chances of success over a complete package of IVF or ICSI treatment.…”

Section: Introductionmentioning

confidence: 99%

Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women

McLernon

Steyerberg

Velde

et al. 2016

BMJ

187

186

View full text Add to dashboard Cite

Objective To develop a prediction model to estimate the chances of a live birth over multiple complete cycles of in vitro fertilisation (IVF) based on a couple’s specific characteristics and treatment information.Design Population based cohort study.Setting All licensed IVF clinics in the UK. National data from the Human Fertilisation and Embryology Authority register.Participants All 253 417 women who started IVF (including intracytoplasmic sperm injection) treatment in the UK from 1999 to 2008 using their own eggs and partner’s sperm.Main outcome measure Two clinical prediction models were developed to estimate the individualised cumulative chance of a first live birth over a maximum of six complete cycles of IVF—one model using information available before starting treatment and the other based on additional information collected during the first IVF attempt. A complete cycle is defined as all fresh and frozen-thawed embryo transfers arising from one episode of ovarian stimulation.Results After exclusions, 113 873 women with 184 269 complete cycles were included, of whom 33 154 (29.1%) had a live birth after their first complete cycle and 48 925 (43.0%) after six complete cycles. Key pretreatment predictors of live birth were the woman’s age (31 v 37 years; adjusted odds ratio 1.66, 95% confidence interval 1.62 to 1.71) and duration of infertility (3 v 6 years; 1.09, 1.08 to 1.10). Post-treatment predictors included number of eggs collected (13 v 5 eggs; 1.29, 1.27 to 1.32), cryopreservation of embryos (1.91, 1.86 to 1.96), the woman’s age (1.53, 1.49 to 1.58), and stage of embryos transferred (eg, double blastocyst v double cleavage; 1.79, 1.67 to 1.91). Pretreatment, a 30 year old woman with two years of unexplained primary infertility has a 46% chance of having a live birth from the first complete cycle of IVF and a 79% chance over three complete cycles. If she then has five eggs collected in her first complete cycle followed by a single cleavage stage embryo transfer (with no embryos left for freezing) her chances change to 28% and 56%, respectively.Conclusions This study provides an individualised estimate of a couple’s cumulative chances of having a baby over a complete package of IVF both before treatment and after the first fresh embryo transfer. This novel resource may help couples plan their treatment and prepare emotionally and financially for their IVF journey.

show abstract

Live-Birth Rate Associated With Repeat In Vitro Fertilization Treatment Cycles

Abstract: Among women in the United Kingdom undergoing IVF, the cumulative prognosis-adjusted live-birth rate after 6 cycles was 65.3%, with variations by age and treatment type. These findings support the efficacy of extending the number of IVF cycles beyond 3 or 4.

Cited by 171 publications

References 30 publications

Fertility outcome of laparoscopic treatment in patients with severe endometriosis and repeated in vitro fertilization failures

Fertility outcome of laparoscopic treatment in patients with severe endometriosis and repeated in vitro fertilization failures

Re-Thinking Elective Single Embryo Transfer: Increased Risk of Monochorionic Twinning - A Systematic Review

Predicting the chances of a live birth after one or more complete cycles of in vitro fertilisation: population based study of linked cycle data from 113 873 women

Contact Info

Product

Resources

About