Live birth of a normal mature healthy baby by in vitro fertilization–embryo transfer (IVF-ET) after an exploratory laparotomy and multiple myomectomy for leiomyomatosis peritonealis disseminata

DeAngelis, Sammy L.; Harris, R. R.; Maiman, Mitchell; Knochenhauer, Eric S.

doi:10.1016/j.fertnstert.2009.01.074

Cited by 2 publications

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“…In animal studies, female guinea pigs were administered extremely high doses of oestrogen and progesterone, which induced the development of leiomyomatous peritoneal lesions similar to those of LPD [9]. Thus, women with long-term oral contraceptive use, pregnancy, endometriosis, or in vitro fertilisation stimulation have high risks for LPD [5,6,10,11,12,13]. Genetic and iatrogenic dissemination could be possible causes of LPD [14].…”

Section: Introductionmentioning

confidence: 99%

A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata

Wu¹,

Wu²,

Chen³

et al. 2015

Gynecol Obstet Invest

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Background: Leiomyomatosis peritonealis disseminata (LPD) is a rare disease characterised by the subperitoneal proliferation of smooth muscle cells that form benign nodules. A few studies have aimed to reveal the pathogenesis of LPD without reaching a clear explanation. Methods: Karyotype analysis and array-comparative genomic hybridization (aCGH) of a human LPD case were performed to evaluate the role of chromosomal abnormalities in LPD pathogenesis. Results: The LPD nodules showed a 45, XX, del(7p), t(11; 17) (q23;q25),-22 de novo karyotype, and the aCGH analysis confirmed these deletions at 7p22.3-p12.1 (1,862,362-52,766,911 bp) and 22q11.23-q13.33 (21,973,915-49,265,116 bp) with lengths of 50.9 Mb and 27.3 Mb, respectively. Conclusion: In this study, we described two large novel aberrations - deletions in chromosome 7 and 22 - that might play an important role in LPD disease. These findings might contribute to new insights to unravel the pathogenesis of LPD and develop further clinical treatments.

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Section: Introductionmentioning

confidence: 99%

A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata

Wu¹,

Wu²,

Chen³

et al. 2015

Gynecol Obstet Invest

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“…Immunohistological staining usually reveals typical smooth muscle tumors with high levels of vimentin, desmin, SMA, and muscle-specific actin expression in tumor sections. Conservative and surgical treatments to preserve fertility are reasonable for women in the reproductive age, particularly for those with fertility requirement, and radical surgery is recommended after giving birth or for those who are at a high-risk for malignant transformation [10].…”

Section: Discussionmentioning

confidence: 99%

A case report of postmenopausal leiomyomatosis peritonealis disseminata

Zhou¹,

Chen²,

Zhang³

et al. 2017

Clin. Exp. Obstet. Gynecol.

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Leiomyomatosis peritonealis disseminata (LPD) is a rare and benign disease, mainly occurred in reproductive age. The authors report a postmenopausal Chinese woman with a large, hard, and unmovable mass in lower abdomen. Computerized tomography revealed a mass of 13.4× 12.0 cm with irregular edges adhering to surrounding organs, with multiple nodules around the abdominal aorta, and in the pelvic peritoneum, mesenteric, and ileocecal regions. She had abnormal higher levels of serum carbohydrate antigen (CA) 125, but normal levels of serum CA 19-9, alpha-fetal protein, and carcinoembryonic antigen. After being treated with epirubicin, carboplatin, and interventional embolization, her abdominal mass was reduced by about 10% and she received a successful radical surgery, including pelvic tumor resection, total hysterectomy, bilateral oophorectomy, omental resection, appendectomy, rectal resection, and anastomosis. Her pelvic mass weighed 1,350 grams and histologically diagnosed as LPD. Immunohistochemistry of the mass showed positive staining of vimentin, caldesmon, smooth muscle actin (SMA), b-catenin, and Bcl-2, but negative for CD10, CD34, CD99, CD117, S-100, progesterone receptor, and DOG1 staining. She had no disease recurrence during a year of follow up.

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Live birth of a normal mature healthy baby by in vitro fertilization–embryo transfer (IVF-ET) after an exploratory laparotomy and multiple myomectomy for leiomyomatosis peritonealis disseminata

Cited by 2 publications

References 0 publications

A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata

A Novel Molecular Cytogenetic Finding of Leiomyomatosis Peritonealis Disseminata

A case report of postmenopausal leiomyomatosis peritonealis disseminata

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