Live birth after transfer of a single euploid vitrified-warmed blastocyst according to standard timing vs. timing as recommended by endometrial receptivity analysis

Clinical outcomes of personalized blastocyst embryo transfer after endometrial receptivity analysis: A multicenter, retrospective cohort study

“…19 On the other hand, Doyle et al investigated 307 patients with ERA-timed, single-euploid FETs and found that there was no significant difference in the proportions of receptive and non-receptive among those who previously failed FETs. 20 They commented that patients with more previously failed euploid FET cycles are not at increased risk of a displaced WOI. Although several studies have analyzed numbers of repeated implantation failures, endometrial P4 and 17α-hydroxyprogesterone expression, and chronic endometritis as factors that may influence receptivity, not all studies drew the same conclusions.…”

Have we been a little overly receptive?

“…In conclusion, Doyle et al (1) have contributed an important clinical study to the literature of ART add-ons. It motivates performing another RCT to determine whether ERA has utility in patients with 1 or more failed euploid FETs because that comes up as a common clinical question posed by patients.…”

“…The study by Doyle et al (1) in this month's Fertility and Sterility examines the use of endometrial receptivity assay (ERA) for improving live birth in euploid frozen embryo transfer (FET) cycles. The investigators conducted a well-done retrospective, large cohort study that included patients with previous failed euploid transfers and those without previous transfers.…”

“…In that case, the clinician may automatically suggest undergoing ERA, pointing to an endometrial factor for the failed implantation. Doyle et al (1) demonstrated that the ERA change in progesterone timing did not affect the success of euploid embryo transfers. This implies that the answer to the question regarding why the previous transfer was not successful does not come from the ERA result.…”

“…This implies that the answer to the question regarding why the previous transfer was not successful does not come from the ERA result. A randomized controlled trial (RCT) will be necessary to answer this question with a higher degree of certainty because even in the case of a well-done retrospective cohort study by Doyle et al (1), confounders biasing the result may still exist.…”