Liubao Insect tea polyphenols prevent HCl/ethanol induced gastric damage through its antioxidant ability in mice

Zhang, Jing; Lu, De-Yun; Yuan, Ying; Chen, Jingxia; Yan, Sha; Chen, Benchou

doi:10.1039/c9ra09641h

Cited by 11 publications

(7 citation statements)

References 38 publications

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“…Cu/Zn-SOD [17] Forward Cu/Zn-SOD: cuprozinc-superoxide dismutase; Mn-SOD: manganese superoxide dismutase; CAT: catalase; TNF-α: tumor necrosis factor alpha; NF-κB: nuclear factor kappa-B; IL-1β: Interleukin-1 beta; GAPDH: glyceraldehyde-3-phosphate dehydrogenase.…”

Section: Gene Name Sequencementioning

confidence: 99%

Improvement Effect of Lotus Leaf Flavonoids on Carbon Tetrachloride-Induced Liver Injury in Mice

et al. 2020

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In this study, the effect of lotus leaf flavonoids (LLF) on carbon tetrachloride (CCl4)-induced liver injury in mice was studied. CCl4 was injected intraperitoneally to induce liver injury in Kunming mice. Mice were treated with LLF by gavage, and the mRNA expression levels in serum and liver were detected. Compared with the model group, LLF significantly reduced the liver index and serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), triglyceride (TG), and total cholesterol (TC) levels in mice with CCl4-induced liver injury. Pathological observation showed that LLF effectively reduced morphological incompleteness and hepatocyte necrosis in CCl4-treated liver tissue. The result of quantitative polymerase chain reaction (qPCR) indicated that LLF significantly up-regulated the mRNA expression levels of copper/zinc superoxide dismutase (Cu/Zn-SOD), manganese superoxide dismutase (Mn-SOD), and catalase (CAT) and down- regulated the expression levels of tumor necrosis factor-alpha (TNF-α), nuclear factor kappa B (NF-κB), and interleukin-1β (IL-1β) (p < 0.05). Thus, LLF is an active ingredient that ameliorates liver injury, and it has good application prospect.

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Section: Gene Name Sequencementioning

confidence: 99%

Improvement Effect of Lotus Leaf Flavonoids on Carbon Tetrachloride-Induced Liver Injury in Mice

et al. 2020

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“…It enhances detoxification, strengthens the stomach and digestion, and exerts free radical scavenging, anti-oxidant, and anti-inflammatory effects ( Zhao et al, 2018 ; Zhu et al, 2019 ; Zhang et al, 2020 ). In this study, We made statistics on the previous research reports ( Lin C. S. et al, 2018 ; Svenja et al, 2020 ; Zhang J. et al, 2020 ; Zhang W. et al, 2020 ; Zhu et al, 2019 ), obtained the active substances that may be contained in Ilex kudingcha and Insect tea, and established a database of biologically active ingredients. 33 bioactive components were detected in ITP and IKDCP by UHPLC-QqQ-MS, with the majority being chlorogenic acid and its isomers, as well as i soquercitrin, kaempferol, dihydroquercetin, naringin .…”

Section: Discussionmentioning

confidence: 99%

“…Next, 1800 ml of distilled water was added at a ratio of 1:9 (v/v), and extraction was conducted at 90°C for 30 min. After a repeat of the extraction, the two extracts were combined, the filtrate was enclosed in a round-bottomed flask, and the liquid was dried by rotary evaporation to obtain IKDCP and ITP ( Zhang J. et al, 2020 ; Zhu et al, 2019 ).…”

Section: Methodsmentioning

confidence: 99%

Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects

Yang

Tan

et al. 2021

Front. Pharmacol.

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Ilex kudingcha C.J. Tseng tea and insect tea, as traditional Chinese teas, are favored for their original craftsmanship, unique flavor, and biological functionality. In this study, ultra high-performance liquid chromatography-triple quadrupole mass spectrometry (UHPLC-QqQ-MS) was used to analyze the bioactive components of the extracts of Ilex kudingcha and insect tea, and D-galactose-induced aging mice were used to compare the in vivo anti-aging effects of Ilex kudingcha and insect tea extracts. The results were remarkable, UHPLC-QqQ-MS analysis showed that ITP contains 29 ingredients, while IKDCP contains 26 ingredients. However, due to the large differences in the content of the main chemical components in IKDCP and ITP, the effects are equally different. At the same time, the in vivo research results suggesting that the anti-aging effects of IKDCP and ITP (500 mg/kg) include the regulation of viscera indices of major organs; improvement in liver, skin, and spleen tissue morphology; decreased production of inflammatory cytokines; up regulation of SOD, CAT, GSH, GSH-PX, and T-AOC and down regulation of NO and MDA levels in serum and liver tissue; reductions in the concentration of pro-inflammatory factors, and increases in the concentration of anti-inflammatory factor. RT-qPCR and western blot assay also showed that IKDCP and ITP affect anti-aging by regulating the gene and protein expression of GSH-PX, GSH1, SOD1, SOD2, and CAT. The overall results indicate that ITP is more effective in treating oxidative damage in aging mice induced by D-galactose. Thus, ITP appears to be an effective functional drink owing to its rich nutritional components and anti-aging activities.

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“…Group 2 (ulcerated group) orally treated with 0.1 ml HCl/EtOH (60% ethanol in 40% 150 mmol/L hydrochloric acid) mixture per 10 g body weight ( Zhang et al, 2020 );…”

Section: Methodsmentioning

confidence: 99%

Therapeutic strategies of Moringa oleifera Lam. (Moringaceae) for stomach and forestomach ulceration induced by HCl/EtOH in rat model

Dalhoumi

Guesmi

Bouzidi

et al. 2022

Saudi Journal of Biological Sciences

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Liubao Insect tea polyphenols prevent HCl/ethanol induced gastric damage through its antioxidant ability in mice

Abstract: The aim of this study was to study the preventive effects of polyphenols extracted from Liubao Insect tea on gastric injury.

Cited by 11 publications

References 38 publications

Improvement Effect of Lotus Leaf Flavonoids on Carbon Tetrachloride-Induced Liver Injury in Mice

Improvement Effect of Lotus Leaf Flavonoids on Carbon Tetrachloride-Induced Liver Injury in Mice

Determination of Polyphenols in Ilex kudingcha and Insect Tea (Leaves Altered by Animals) by Ultra-high-performance Liquid Chromatography-Triple Quadrupole Mass Spectrometry (UHPLC-QqQ-MS) and Comparison of Their Anti-Aging Effects

Therapeutic strategies of Moringa oleifera Lam. (Moringaceae) for stomach and forestomach ulceration induced by HCl/EtOH in rat model

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