Littoral cell angioma of the spleen: A case report

Opatrný, Václav; Třeška, Vladislav; Waloschek, Tomáš; Moláček, Jiří

doi:10.1177/2050313x20959874

Cited by 6 publications

(14 citation statements)

References 8 publications

(11 reference statements)

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“…A total of 60 various malignant tumors co-occurred with LCA ( 1 , 11 , 12 , 31 – 65 ), as shown in Table 1 and Figure 2 , with a comorbidity rate of 13.8%. A total of 59 patients had comorbid malignancies, which occurred before the formation of LCA.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, 19 LCA patients underwent radionuclide imaging ( Table 3 ). In nine patients who underwent positron emission tomography/CT examination, 7 who developed the splenic lesions had no abnormal uptake ( 11 , 32 , 33 , 35 , 36 , 65 , 93 ) ( Figure 3C ). However, 2 patients showed high uptake of 18F-fluorodeoxyglucose ( 11 , 94 ).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 18 patients described the natural history of LCA. Detailed description of the period of LCA formation was provided for ten patients (19,26,38,42,45,65,70,76,100,101). The median time for LCA formation was 15 m, with the shortest and longest being 26 d and 4 y, respectively.…”

Section: Characteristics Of Spleen and Lcamentioning

confidence: 99%

“…The median time for LCA formation was 15 m, with the shortest and longest being 26 d and 4 y, respectively. Eleven patients with untreated LCA survived during follow-up, which had no obvious symptoms of discomfort (16,19,43,65,71,(102)(103)(104)(105)(106)(107). The median of follow-up time of patients with untreated LCA was 24 m, with the shortest and longest being 0.5 m and 9 y.…”

Section: Characteristics Of Spleen and Lcamentioning

confidence: 99%

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Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Wang

Zhao

et al. 2022

Front. Oncol.

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ObjectiveLittoral cell angioma (LCA) is currently considered to be a rare splenic tumor with malignant potential. As the epidemiology, pathogenesis, clinical manifestation, treatment, and prognosis remain unclear, the clinical diagnosis and treatment of LCA have not been standardized. Hence, we performed a comprehensive analysis of 189 observational studies comprising 435 patients to improve the current status of diagnosis and treatment.MethodsPubMed, Embase, WanFang and CNKI were searched from inception to May 2021 to identify LCA studies that were published in English and Chinese. The clinical information of LCA patients were extracted and analyzed.ResultsThe LCA has a male-to-female ratio of 0.90 and a solitary-to-multiple ratio of 0.31. In terms of clinical features, 69.7% of the patients showed splenomegaly, 49.7% were asymptomatic, and 39.2% experienced epigastric discomfort. As the imaging findings of patients with LCA were nonspecific, an image-guided biopsy (10/12) was a safe and effective method for diagnosing in this condition. Notably, results of the prognostic analysis indicated that LCA has a lower risk of recurrence and metastasis. The patient may develop a stable disease or the tumor will grow but will not metastasize. Besides, the novel immunohistochemical pattern of LCA was described as CD31+/ERG+/FVIII Antigen+/CD68+/CD163+/lysozyme+/CD8−/WT1−.ConclusionLCA should be reconsidered as a benign primary splenic vascular neoplasm, which is more like an intra-splenic manifestation of abnormal body function. Image-guided biopsy with follow-up might be a beneficial choice for LCA patients. For LCA patients with abdominal discomfort, pathological uncertainty or continuous tumor enlargement, splenectomy remains the preferred treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Spleen and Lcamentioning

confidence: 99%

Section: Characteristics Of Spleen and Lcamentioning

confidence: 99%

See 2 more Smart Citations

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Wang

Zhao

et al. 2022

Front. Oncol.

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“…On CT, it is expected to observe a well-demarcated and hypodense mass. On T2, the mass would be hyperintense, while in T1, it would be hypointense [7] . In theory, doing a fine needle aspirate cytology could help with the diagnosis.…”

Section: Discussionmentioning

confidence: 98%

Case report: Infrequent littoral cell angioma of the spleen

Roldan-Vasquez

Jarrin-Estupiñan

et al. 2021

International Journal of Surgery Case Reports

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Introduction and importance Littoral cell angioma is a rare solid spleen tumor with uncertain malignant potential. It is usually asymptomatic; therefore, its diagnosis is usually incidental. There are approximately 150 cases reported in the medical literature, but none of them in the Hispanic population. Case presentation We present a case of a 54-year-old woman who presented to our clinic with nonspecific abdominal pain. Imaging studies show a splenic mass with littoral cell angioma characteristics. The patient underwent an open splenectomy with subsequent histopathologic and immunohistochemical studies that confirmed the presence of a littoral cell angioma of a diameter of 8 × 4.5 × 3.5 cm. The patient was discharged after an uneventful postoperative recovery and was referred to the outpatient clinic for follow up. Clinical discussion This case report highlights the close relationship between the littoral cell angioma, neoplasias, and autoimmune diseases. Even though LCA has a good prognosis, there is still the possibility of malignant transformation, especially when the spleen weighs 1500 g; our patient's sample pointed towards a benign pathology. LCA has a positive IHC for endothelial and histiocyte tissues. The IHC results of our patient were positive for CD34 + and CD68 + , confirming the LCA diagnosis. Conclusion Within red pulp spleen tumors, LCA should be highly considered as a differential diagnosis in all types of populations. In the case of a confirmed LCA, routine screening for neoplasias and autoimmune diseases should be performed.

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Early postsurgical lethal outcome due to splenic littoral cell angioma: A case report

Fan¹,

Lin²,

Li³

et al. 2023

World J Clin Cases

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BACKGROUND Littoral cell angioma (LCA) is a rare benign vascular tumor of the spleen. Given its rarity, standard diagnostic and therapeutic recommendations have yet to be developed for reported cases. Splenectomy is the only method of obtaining a pathological diagnosis and providing treatment to obtain a favorable prognosis. CASE SUMMARY A 33-year-old female presented with abdominal pain for one month. Computed tomography and ultrasound revealed splenomegaly with multiple lesions and two accessory spleens. The patient underwent laparoscopic total splenectomy and accessory splenectomy, and splenic LCA was confirmed by pathology. Four months after surgery, the patient presented with acute liver failure, was readmitted, rapidly progressed to multiple organ dysfunction syndrome and died. CONCLUSION Preoperative diagnosis of LCA is challenging. We systematically reviewed online databases to identify the relevant literature and found a close relationship between malignancy and immunodysregulation. When a patient suffers from both splenic tumors and malignancy or immune-related disease, LCA is possible. Due to potential malignancy, total splenectomy (including accessory spleen) and regular follow-up after surgery are recommended. If LCA is diagnosed after surgery, a comprehensive postoperative examination is needed.

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Littoral cell angioma of the spleen: A case report

Cited by 6 publications

References 8 publications

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Case report: Infrequent littoral cell angioma of the spleen

Early postsurgical lethal outcome due to splenic littoral cell angioma: A case report

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