Littoral cell angioma of spleen

Truong, Van Tri; Finch, Robert J.; Martin, Benjamin F.; Buzacott, Kate; Singh, Mahendra; Patel, Bhavik

doi:10.1111/ans.14193

Cited by 7 publications

(10 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 60 various malignant tumors co-occurred with LCA ( 1 , 11 , 12 , 31 – 65 ), as shown in Table 1 and Figure 2 , with a comorbidity rate of 13.8%. A total of 59 patients had comorbid malignancies, which occurred before the formation of LCA.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, LCA could appear as multifocal lesions or a solitary nodule with a solitary-to-multiple ratio of 0.31 in 349 patients. The average diameter of solitary LCA was 6.4 ± 4.0 cm, with the maximum diameter being 21 cm ( 31 ). The average diameter of solitary LCA was only 3.3 ± 2.6 cm in the multiple LCA group, with the maximum diameter being 18 cm ( 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…In fact, solitary LCA was not uncommon with a solitary-to-multiple ratio of 0.31 (83/266). In terms of size, LCA ranged from small foci that are unremarkable in the splenic parenchyma to large lesions that are almost completely replacing the splenic parenchyma, with a known maximum diameter of 21 cm ( 31 ). Furthermore, a novel panel of immunohistochemical staining for LCA was recommended as CD31 + /ERG + /FVIII antigen + /CD68 + /CD163 + /lysozyme + /CD8 − /WT1 − by summing up the previous pathological findings, which would help distinguish from other primary or secondary splenic tumors.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Wang

Zhao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

ObjectiveLittoral cell angioma (LCA) is currently considered to be a rare splenic tumor with malignant potential. As the epidemiology, pathogenesis, clinical manifestation, treatment, and prognosis remain unclear, the clinical diagnosis and treatment of LCA have not been standardized. Hence, we performed a comprehensive analysis of 189 observational studies comprising 435 patients to improve the current status of diagnosis and treatment.MethodsPubMed, Embase, WanFang and CNKI were searched from inception to May 2021 to identify LCA studies that were published in English and Chinese. The clinical information of LCA patients were extracted and analyzed.ResultsThe LCA has a male-to-female ratio of 0.90 and a solitary-to-multiple ratio of 0.31. In terms of clinical features, 69.7% of the patients showed splenomegaly, 49.7% were asymptomatic, and 39.2% experienced epigastric discomfort. As the imaging findings of patients with LCA were nonspecific, an image-guided biopsy (10/12) was a safe and effective method for diagnosing in this condition. Notably, results of the prognostic analysis indicated that LCA has a lower risk of recurrence and metastasis. The patient may develop a stable disease or the tumor will grow but will not metastasize. Besides, the novel immunohistochemical pattern of LCA was described as CD31+/ERG+/FVIII Antigen+/CD68+/CD163+/lysozyme+/CD8−/WT1−.ConclusionLCA should be reconsidered as a benign primary splenic vascular neoplasm, which is more like an intra-splenic manifestation of abnormal body function. Image-guided biopsy with follow-up might be a beneficial choice for LCA patients. For LCA patients with abdominal discomfort, pathological uncertainty or continuous tumor enlargement, splenectomy remains the preferred treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Wang

Zhao

et al. 2022

Front. Oncol.

View full text Add to dashboard Cite

show abstract

“…LCA is an asymptomatic pathology in more than 55% of cases [6] . In the rest of the patients, it can present diffuse abdominal pain and fever.…”

Section: Discussionmentioning

confidence: 99%

Case report: Infrequent littoral cell angioma of the spleen

Roldan-Vasquez

Jarrin-Estupiñan

et al. 2021

International Journal of Surgery Case Reports

View full text Add to dashboard Cite

Introduction and importance Littoral cell angioma is a rare solid spleen tumor with uncertain malignant potential. It is usually asymptomatic; therefore, its diagnosis is usually incidental. There are approximately 150 cases reported in the medical literature, but none of them in the Hispanic population. Case presentation We present a case of a 54-year-old woman who presented to our clinic with nonspecific abdominal pain. Imaging studies show a splenic mass with littoral cell angioma characteristics. The patient underwent an open splenectomy with subsequent histopathologic and immunohistochemical studies that confirmed the presence of a littoral cell angioma of a diameter of 8 × 4.5 × 3.5 cm. The patient was discharged after an uneventful postoperative recovery and was referred to the outpatient clinic for follow up. Clinical discussion This case report highlights the close relationship between the littoral cell angioma, neoplasias, and autoimmune diseases. Even though LCA has a good prognosis, there is still the possibility of malignant transformation, especially when the spleen weighs 1500 g; our patient's sample pointed towards a benign pathology. LCA has a positive IHC for endothelial and histiocyte tissues. The IHC results of our patient were positive for CD34 + and CD68 + , confirming the LCA diagnosis. Conclusion Within red pulp spleen tumors, LCA should be highly considered as a differential diagnosis in all types of populations. In the case of a confirmed LCA, routine screening for neoplasias and autoimmune diseases should be performed.

show abstract

“…Several studies have shown an association of LCA with immune system dysfunction, including Crohn disease, and Gaucher disease, but almost no association was reported between LCA and visceral tumors including renal cell cancer and seminoma. [ 8 , 9 ]…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic splenectomy for littoral cell angioma of the spleen

Zhou

Cao

et al. 2019

Medicine

View full text Add to dashboard Cite

Rationale:Littoral cell angioma (LCA) is a rare primary vascular neoplasm of the spleen. It can be benign or malignant. Pathology and immunohistochemistry are the gold standards for the diagnosis of LCA. Therefore, splenectomy is recommended for the purpose of diagnosis and treatment, and subsequent follow-up is necessary. There are limited reports about LCA. Here, we present a case of a female patient with LCA undergoing laparoscopic splenectomy in order to provide clinical experience in LCA treatment.Patient concerns:A 32-year-old female attended the outpatient Department of Hepatobiliary Surgery for follow-up of hepatic hemangiomas. The patient presented with intermittent abdominal distension, which was slightly under no obvious inducement.Diagnosis:Physical examination found no signs of abdominal tenderness and rebound tenderness, and liver and spleen were impalpable. The contrast-enhanced computed tomography (CT) showed multiple space-occupying lesions in the spleen, mottled low-density lesions, multiple hypoattenuating nodules with no contrast enhancement on the arterious phase. Delayed contrast-enhanced helical CT scan displayed incomplete filling of hypodense splenic lesions.Interventions:Given that it was uncertain whether it was a benign or a malignant tumor, a laparoscopic total splenectomy was performed.Outcomes:The final pathological diagnosis was LCA. Her postsurgical course was uneventful, and no surgery-related complications were found. No signs of recurrence were observed in the 16 months after the operation.Lessons:LCA was a rare primary vascular neoplasm of the spleen, and laparoscopic splenectomy for LCA was safe and feasible, and postoperative course was uneventful. However, regular follow-up and long-time monitoring after splenectomy for LCA is recommended because of its potential malignant biological behavior.

show abstract

Littoral cell angioma of spleen

Cited by 7 publications

References 4 publications

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Clinical Landscape of Littoral Cell Angioma in the Spleen Based on a Comprehensive Analysis

Case report: Infrequent littoral cell angioma of the spleen

Laparoscopic splenectomy for littoral cell angioma of the spleen

Contact Info

Product

Resources

About