Litt's Drug Eruptions & Reactions Manual

Cyclosporine in Stevens Johnson syndrome and toxic epidermal necrolysis and retrospective comparison with systemic corticosteroid

“…The reported ability or likelihood of a drug being the cause of SJS/TEN can be found in PubMed/MedLine or other appropriate sources such as the Litt's drug eruption reference manual. [42] SJS/TEN is a life-threatening condition and therefore supportive care should be an essential part of the management strategy. [1] Our study was distinct in the way, it had evaluated the efficacy of cyclosporine and compared historically to corticosteroids.…”

Acute Generalized Exanthematous Pustulosis Associated with Tigecycline

“…The literature reports that drug-related AGEP develops in less than 24 hours1,5. There are also reports in the literature of cases developing after acute viral infections and spider bites.…”

“…Various cutaneous reactions have been defined with tigecycline; but no AGEP cases have been reported1.…”

“…Acute generalized exanthematous pustulosis (AGEP) is a rare and severe cutaneous reaction with a sudden onset on the erythematous skin characterized by small and sterile pustules, fever and leukocytosis, and a lack of follicular localization1. AGEP was first described by Beylot and colleagues2 in France as a generalized pustular eruption with a sudden onset in the patients without a history of psoriasis.…”

“…AGEP associated with tigecycline has not been reported in literature; but it has been reported that this drug can cause various cutaneous reactions1.…”