Litiasis medicamentosa en pacientes VIH + en tratamiento con Indinavir

Escudero, Joaquín; Alcina, Emilio López; Domínguez, Felipe Ordoño; Deltoro, M. Fabuel; Torrijos, Francisco Serrano de la Cruz; García, A. Fernández; Benlloch, Francisco Ramada; Vidal, Elsie González

doi:10.4321/s0004-06142008000100005

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…As indinavir is poorly soluble at pH 45, urinary acidification, increased fluid intake, and, if possible, discontinuation of therapy may dissolve stones. [119][120][121][122][123][124] Other medications precipitating in the urine but rarely causing stones include ceftriaxone, sulfonamides, ampicillin, amoxicillin, triamteren, acyclovir, and oxypurine.…”

Section: Urinary Tract Infectionsmentioning

confidence: 99%

Nephrocalcinosis and urolithiasis in children

Habbig

Beck

Höppe

2011

Kidney International

138

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The incidence of adult urolithiasis has increased significantly in industrialized countries over the past decades. Sound incidence rates are not available for children, nor are they known for nephrocalcinosis, which can appear as a single entity or together with urolithiasis. In contrast to the adult kidney stone patient, where environmental factors are the main cause, genetic and/or metabolic disorders are the main reason for childhood nephrocalcinosis and urolithiasis. While hypercalciuria is considered to be the most frequent risk factor, several other metabolic disorders such as hypocitraturia or hyperoxaluria, as well as a variety of renal tubular diseases, e.g., Dent's disease or renal tubular acidosis, have to be ruled out by urine and/or blood analysis. Associated symptoms such as growth retardation, intestinal absorption, or bone demineralization should be evaluated for diagnostic and therapeutic purposes. Preterm infants are a special risk population with a high incidence of nephrocalcinosis arising from immature kidney, medication, and hypocitraturia. In children, concise evaluation will reveal an underlying pathomechanism in >75% of patients. Early treatment reducing urinary saturation of the soluble by increasing fluid intake and by providing crystallization inhibitors, as well as disease-specific medication, are mandatory to prevent recurrent kidney stones and/or progressive nephrocalcinosis, and consequently deterioration of renal function.

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Section: Urinary Tract Infectionsmentioning

confidence: 99%

Nephrocalcinosis and urolithiasis in children

Habbig

Beck

Höppe

2011

Kidney International

138

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“…Patients with chronic hepatitis C coinfection have a greater risk of lithiases. Indinavir-associated calculi are very small (2-6 mm) and they are usually eliminated, but tubular deposition may cause post-renal obstructive failure [4][5][6]. Ganciclovir is also nephrotoxic and it produces intratubular crystal precipitation.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Uropathy Secondary to Antiretroviral Agents

Mastrapasqua¹

2017

UNOAJ

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Acute kidney injury (AKI) and chronic kidney disease (CKD) are more common in HIV-infected patients than in the general population. We observed an HIV(+) young man who presents an unusual cause of acute renal injury (obstructive uropathy as a consequence of lithiases secondary to antiretroviral therapy). The differential diagnosis of kidney diseases associated with HIV infections includes: glomerular, tubular and interstitial causes. A renal biopsy is a useful tool in the diagnostic approach. Nephrologists and urologists must be aware of HIV-related renal affection, including toxicity related to HAART schedules.

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“…Com a introdução de novos e potentes inibidores de proteases para o tratamento do HIV observou-se significante redução da mortalidade com concomitante aumento na sobrevida dos pacientes infectados. No entanto, têm-se descrito vários efeitos secundários em seres humanos associados ao uso destes medicamentos como a resistência à insulina (CARON et al, 2001), nefropatias, litíase, aumento do risco de infarto do miocárdio (NOOR et al, 2002;COLLIN et al, 2007;ESCUDERO et al, 2008), entre doenças cardíacas dado por efeitos secundários como a hiperlipidemia, lipodistrofia (redistribuição anormal da gordura corporal), diminuição dos níveis séricos de HDL (CALZA et al, 2004), entre outros.…”

Section: Discussionunclassified

Avaliação do modelo de hamster para detecção das alterações lipídicas e cardiotoxicidade associadas à terapia contra o vírus da imunodeficiência humana

Sanchez¹

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Litiasis medicamentosa en pacientes VIH + en tratamiento con Indinavir

Cited by 3 publications

References 12 publications

Nephrocalcinosis and urolithiasis in children

Nephrocalcinosis and urolithiasis in children

Obstructive Uropathy Secondary to Antiretroviral Agents

Avaliação do modelo de hamster para detecção das alterações lipídicas e cardiotoxicidade associadas à terapia contra o vírus da imunodeficiência humana

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