Lithospermic acid B as an antioxidant-based protector of cultured ventricular myocytes and aortic endothelial cells of rabbits

Funh, K.P.; Wu, Jun; Zeng, Ling-Hua; Wong, Helen; Lee, C.M.; Hon, Po‐Ming; Chang, Han-Lin; Wu, Tai-Wing

doi:10.1016/0024-3205(93)90129-q

Cited by 10 publications

(14 citation statements)

References 11 publications

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“…Since antioxidants can protect low density lipoprotein from oxidation and thus inhibit the progress of atherosclerosis (Aviram, 2000;Karmin et al, 2001), and antioxidant effect has been regarded as mechanisms of anti-ischemia-reperfusion (Wu et al, 2001) and protection of ventricular myocytes and aortic endothelial cells against necrosis (Fung et al, 1993). Thus results of this investigation support the usage of Pueraria lobata and Pueraria thomsonii respectively in the clinic application and as dietary supplement for prevention of cardiovascular diseases.…”

Section: Resultsmentioning

confidence: 57%

A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis

Jiang

Lau

Lam

et al. 2005

Journal of Ethnopharmacology

112

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Section: Resultsmentioning

confidence: 57%

A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis

Jiang

Lau

Lam

et al. 2005

Journal of Ethnopharmacology

112

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“…These compounds have been shown to have a protective action against peroxidative damage to biomembranes of liver microsomes, hepatocytes and erythrocytes of rats (29). Lithospermic acid B has been demonstrated to be an effective antioxidant-based myocardial protector (30), and it also had a hypotensive effect in anesthetized rats (31). A water extract of SM has been reported to inhibit collagen secretion in cultured human skin fibroblasts (32).…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells

Ouyang

Takahashi²,

Komatsu³

et al. 2001

Japanese Journal of Pharmacology

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ABSTRACT-The effect of the root of Salvia miltiorrhiza (SM) on angiotensin II (Ang II)-induced hypertrophic responses was examined in cultured neonatal rat cardiac cells (cardiomyocytes and non-cardiomyocytes). The methanol eluate fraction (SM2) of the water extract and the ethyl acetate-insoluble fraction (SM3) and its soluble fraction (SM4) partitioned from the methanol extract were prepared. Treatment with SM4 (5 -80 mg/ml), not SM2 and SM3, for 24 h produced dose-dependent cytotoxicity against cardiac cells relative to the reduction in viability and the morphological injury of cardiomyocytes. SM2 or SM3 in the absence of Ang II affected neither hyperplastic nor hypertrophic growth of both cell types. However, SM3 (40 mg/ml) attenuated the positive chronotropic responsiveness of cardiomyocytes to Ang II (1 nM) stimulation, whereas Ang II-induced increase in non-cardiomyocyte number was decreased only by SM2 (40 m g/ml) treatment. Furthermore, SM3 suppressed Ang II-induced enlargement of cell size by preceding Ang IIinduced induction of immediate early response gene (c-jun) expression in cardiomyocytes, while SM2 decreased Ang II-induced DNA synthesis in non-cardiomyocytes. Moreover, three phenolic compounds and tanshinone IIA that differed quantitatively among three SM fractions were identified by reverse-phase high performance liquid chromatography. Thus, the present findings indicate that the root of SM is an effective inhibitor of Ang II action and has a plural effective constituent, which possess different pharmacological activities on Ang II-induced hypertrophy and hyperplasia in cultured neonatal rat cardiac cells.

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“…It is important to show that MLB reduces the myocardial infarct size in an ischemia -reperfusion rabbit model (Fung et al, 1993b), which is directly related to the beneficial effects of Danshen in the treatment of coronary heart diseases. The cardiac protective effect of MLB was also demonstrated in two different in vitro models (Fung et al, 1993a;Au-Yeung et al, 2001). Since Ca 2+ antagonists effectively protect myocardium from ischemic injury (Watts et al, 1986), we speculated that MLB might exert the protective effects via blocking of Ca 2+ channels.…”

Section: Introductionmentioning

confidence: 96%

Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes

Wang

2006

Life Sciences

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Lithospermic acid B as an antioxidant-based protector of cultured ventricular myocytes and aortic endothelial cells of rabbits

Cited by 10 publications

References 11 publications

A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis

A comparative study on aqueous root extracts of Pueraria thomsonii and Pueraria lobata by antioxidant assay and HPLC fingerprint analysis

Protective Effect of Salvia miltiorrhiza on Angiotensin II-Induced Hypertrophic Responses in Neonatal Rat Cardiac Cells

Selective modulation of L-type calcium current by magnesium lithospermate B in guinea-pig ventricular myocytes

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