Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats

Kang, Eun Seok; Lee, Geun Taek; Kim, Beom Seok; Kim, Chul Hoon; Seo, Gi Ho; Han, Seung Jin; Hur, Kyu Yeon; Ahn, Chul Woo; Ha, Hunjoo; Jung, Mankil; Ahn, Young Soo; Soo, Bong; Lee, Hyun Chul

doi:10.1016/j.ejphar.2007.10.070

Cited by 34 publications

(20 citation statements)

References 38 publications

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“…In in vivo studies, MLB treatment effectively inhibited diabetes-associated TGF-β1, fibronectin and collagen upregulation in the renal cortex and significantly suppressed the progression of renal injury in streptozotocin-induced diabetic rats (STZR) [95] . Similar effects were found in Otsuka Long-Evans-Tokushima Fatty (OLETF) rats with type 2 diabetes [96] . The results of these studies suggest that MLB may be a promising therapeutic agent for preventing and treating diabetic nephropathy.…”

Section: Inhibitory Effects On Liver Fibrosissupporting

confidence: 60%

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

Wang

2012

Acta Pharmacol Sin

103

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Salvia miltiorrhiza, a traditional medical herb known as danshen, has been widely used in China to improve blood circulation, relieve blood stasis, and treat coronary heart disease. S miltiorrhiza depside salt is a novel drug recently developed at the Shanghai Institute of Materia Medica; it contains magnesium lithospermate B (MLB) and its analogs, rosmarinic acid (RA) and lithospermic acid (LA), as active components. The drug has been used in the clinic to improve blood circulation and treat coronary heart disease. The pharmacological effects of the depside salt from S miltiorrhiza and its components have been extensively investigated. Experimental studies have demonstrated that magnesium lithospermate B possesses a variety of biological activities, especially protective effects in the cardiovascular system such as attenuation of atherosclerosis and protection against myocardial ischemia-reperfusion injury. Rosmarinic acid and lithospermic acid also show beneficial effects on the cardiovascular system. This paper reviews the recent findings regarding the mechanisms underlying the pharmacological actions of the active components of S miltiorrhiza depside salt, based on published works and our own observations.

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Section: Inhibitory Effects On Liver Fibrosissupporting

confidence: 60%

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

Wang

2012

Acta Pharmacol Sin

103

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“…However, identification of the active compounds and how the extract acts against renal disease remain unclear. Some reports suggest that Sal B has protective effects in patients with renal disease (Jung et al, 2002;Lee et al, 2003;Kang et al, 2004Kang et al, , 2008Chen et al, 2006). Our recent study showed that Sal B prevents TGF-β1-induced EMT (Yao et al, 2009).…”

Section: Introductionmentioning

confidence: 96%

Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β

Pan¹,

Xie

Chen

et al. 2011

Arch. Pharm. Res.

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Salvianolic acid B (Sal B) is the most abundant bioactive molecule from Radix Salviae Miltiorrhizae, and has recently been used for treating renal fibrosis in traditional Chinese medicine. Here we investigated the ability reversal of Sal B to reverse the transdifferentiation of human kidney proximal tubular epithelial cells that was induced by transforming growth factor-beta 1 (TGF-β1). The effects of Sal B on HK-2 cell morphology were observed by phase contrast microscopy, while alpha smooth muscle actin and E-cadherin were studied by immunocytochemistry and real-time reverse transcription polymerase chain reaction, respectively. Exposure of HK-2 cells to TGF-β1 for 72 h induced a complete conversion of the epithelial cells to myofibroblasts. When HK-2 cells were co-incubated with Sal B and TGF-β1 for a further 72 h, the morphology of myofibroblasts returned to that of proximal tubular epithelial cells, whereas the myofibroblast phenotype was maintained after exposure of cells to TGF-β1 for 144 h. Sal B reduced alpha smooth muscle actin levels and increased E-cadherin levels compared with their epithelial-to-mesenchymal transition controls. The reversal effect of Sal B was dose-dependent. That Sal B reverses the epithelial-to-mesenchymal transition in vitro suggests that it could possibly facilitate the repair of tubular epithelial structures and the regression of renal fibrosis in injured kidneys.

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“…Interestingly, oxidative stress has been suggested as a common product of much of mechanisms that are involved in pathogenesis of diabetic nephropathy (2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). In fact, in the tangle web of diabetic nephropathy pathogenesis, oxidative stress activates other pathogenic pathways, other pathways make injury via oxidative stress, and oxidative stress directly leads to injury.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, reactive oxygen species (ROS) and other free radicals can directly induce injury. Oxidative stress activate pathogenic pathways such as RAS, polyol pathway, PKC-B and AGEs (1)(2)(3)(4)(5)(6)(7)(8). AgII activate NADPH oxidase that leads to the superoxide ions formation (1-7-9).…”

Section: Resultsmentioning

confidence: 99%

“…Some of these pathways are: increasing and activation of intra-renal rennin angiotensin system (RAS), formation of advanced glycation end products (AGEs), polyol pathway activation, aldol reductase activation, activation of protein kinase C (PKC), increase of some cytokines -such as insulin like growth factor-1 (IGF-1), transforming growth factor beta (TGF-β)-and the oxidative stress pathway (1)(2)(3)(4)(5).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Diabetic nephropathy and antioxidants

Tavafi¹

2013

J Nephropathol

132

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Lithospermic acid B ameliorates the development of diabetic nephropathy in OLETF rats

Cited by 34 publications

References 38 publications

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components

Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β

Diabetic nephropathy and antioxidants

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