The Trans-Hudson Orogen (THO) of North America is one of the earliest orogens in Earth's history that evolved through a complete Wilson Cycle. It represents c. 150 Ma of opening of the Manikewan Ocean, from c. 2.07-1.92 Ga, followed by its demise in the interval 1.92-1.80 Ga, during the final phase of growth of the Supercontinent Columbia (Nuna). It is characterized by three lithotectonic divisions: (i) Churchill margin (or peri-Churchill); (ii) Reindeer Zone; and (iii) Superior margin (or peri-Superior). The peri-Churchill realm records progressive outward continental growth by accretion of Archaean to Palaeoproterozoic micro-continents (Hearne, Meta Incognita/Core Zone, Sugluk) and eventually arc terranes (La Ronge-Lynn Lake) to the Slave-Rae nuclei, with attendant development of orogenies and basin inversions related to the specific accretion events (1.92-1.89 Ga Snowbird; 1.88-1.865 Ga Foxe; 1.87-1.865 Ga Reindeer orogenies). The Reindeer Zone is characterized by primitive to evolved oceanic arcs, back-arc basins, oceanic crust and ocean plateaus that formed during closure of the Manikewan Ocean, and accretion of a micro-continent (Sask Craton) and smaller Archaean crustal fragments. The terminal phase of the Trans-Hudson orogeny represents collision between the Superior craton, the Reindeer Zone and the composite western Churchill Province during the interval 1.83-1.80 Ga.