Lithocarpic acids O–S, five homo-cycloartane derivatives from the cupules of Lithocarpus polystachyus

The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects ofLithocarpus polystachyus(sweet tea) on APAP-induced oxidative stress injury in mice

“…is mainly distributed in wild mountainous terrain which is rich in plant resources. 10,11 It has the popular name "sweet tea" (ST) in folk medicine and serves as a traditional herbal medicine against various diseases. [12][13][14] The tender leaves of L. polystachyus have been used as a traditional Chinese herb and a sweet tonic drink for several hundreds of years in southern China.…”

Phytochemical identification of Lithocarpus polystachyus extracts by ultra‐high‐performance liquid chromatography–quadrupole time‐of‐flight–MS and their protein tyrosine phosphatase 1B and α‐glucosidase activities

“…Previous chemical studies on L. polystachyus had isolated and identified only some types of compounds such as flavonoids (phloridzin/phlorizin, trilobatin, and quercetin; Dong et al, ; Wang et al, ) or 3,4‐seco‐cycloartane derivatives (lithocarpic acids A–N, lithocarpic acids O–S; Ning et al, ; Wang et al, ). In addition, an ultra‐high‐performance liquid chromatography (UHPLC)–photodiode array/electrospray ionization (ESI)–MS n method was established to identify 68 phenolic compounds in water extract and 22 metabolites in rat plasma, urine, and feces after oral administration of L. polystachyus extract (Li et al, ; Zhao et al, ).…”

Bioactive Triterpenoids from the Leaves and Twigs of Lithocarpus litseifolius and L. corneus

“…As a result, four new triterpenoids (1)(2)(3)(4), three triterpenoids [3,4-seco-4(23),20(29)-lupadiene-3,28dioic acid (5), 3,4-seco-olean-4(23),12-diene-3,28-dioic acid (6), and 3,4-seco-ursan-4(23),12-diene-3,28-dioic acid (7)] were isolated for the first time from a natural source [12,13] (▶ Fig. 1), and six known compounds [3-epi-betulinic acid (8), betulinic acid (9), betulonic acid (10), cylicodiscic acid (11), lupeol (12), and 3epi-glutinol (13)] were identified [14][15][16][17][18][19]. In addition, four known triterpenoids [alphitolic acid (14), 2α,3β,28-lup-20(29)-en-triol (15), maslinic acid (16), and corosolic acid (17)] were isolated from the leaves and twigs of L. corneus [20][21][22][23].…”

“…In previous pharmacological studies, Lithocarpus plants were reported to have anti-tumor [1], anti-hyperglycemic [2], anti-hypertensive [3], anti-inflammatory [4], and anti-oxidant [5] activities. Triterpenes [6][7][8][9], steroids [7], chalcones [10], and various phenolic compounds [4] were found to be major constituents of Lithocarpus plants. Lithocarpus litseifolius (Hance) Schott (syn.…”