Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism

Weinsanto, Ivan; Mouheiche, Jinane; Laux-Biehlmann, Alexis; Aouad, Maya; Maduna, Tando; Petit-Demoulière, Nathalie; Chavant, Virginie; Poisbeau, Pierrick; Darbon, Pascal; Charlet, Alexandre; Giersch, Anne; Parat, Marie-Odile; Goumon, Yannick

doi:10.1177/1744806917754142

Cited by 12 publications

(10 citation statements)

References 56 publications

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“…The current study showed that single treatment of NP in experimental animals with either LiCl or Vit E mitigated the development of mechanical hyperalgesia in CCI‐induced Wistar rats. These were consistent with previous studies on laboratory animal model of NP 12,17,21 . Combined treatment with Vit E and LiCl showed a more robust anti‐nociceptive effect on CCI‐induced NP in Wistar rats.…”

Section: Discussionsupporting

confidence: 92%

“…These were consistent with previous studies on laboratory animal model of NP. 12,17,21 Combined treatment with Vit E and LiCl showed a more robust anti-nociceptive effect on CCIinduced NP in Wistar rats. This indicates a strong synergistic interaction between Vit E and LiCl.…”

Section: Discussionmentioning

confidence: 97%

“…Neuropathic pain (NP) is a severe form of long‐lasting pain that is associated with traumatic injuries to the somatosensory nervous systems 28 . The use of metals, oxidative scavengers, and anti‐inflammatory agents as a form of therapeutic intervention continue to gain the focus at various research level 10,17,29,30 . A combination of 2 or more therapeutic agents has been recommended to be effective for the treatment of NP 11 .…”

Section: Discussionmentioning

confidence: 99%

“…28 The use of metals, oxidative scavengers, and anti-inflammatory agents as a form of therapeutic intervention continue to gain the focus at various research level. 10,17,29,30 A combination of 2 or more therapeutic agents has been recommended to be effective for the treatment of NP. 11 In this study, we reported the anti-nociceptive effects of Vit E, LiCl, and its combination in CCI-induced NP in Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

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Effects of co‐administration of vitamin E and lithium chloride on chronic constriction injury‐induced neuropathy in male Wistar rats: Focus on antioxidant and anti‐inflammatory mechanisms

2021

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Objectives This study investigated the antinociceptive effects of co‐administration of lithium chloride (LiCl) and vitamin E (Vit E) on chronic constriction injury (CCI)‐induced peripheral neuropathy in male Wistar rats. It further explored the anti‐inflammatory and neuroprotective properties of LiCl and Vit E, which may be complementary to the antinociceptive effects of the two substances. Methods Thirty‐six male Wistar rats, 190.00 ± 10.00 g of body weight were randomly assigned to 6 experimental groups and administered with normal saline, Vit E, LiCl, or their combination, once daily for 21 days. CCI was used to induce neuropathic pain (NP) and mechanical allodynia was assessed using von Frey filaments and pinprick test. Open field maze (OFM) was used to assess the exploratory behavior. Biochemical parameters were assessed in the dorsal root ganglion after 21 days of treatment. Results Mechanical allodynia was developed in rats following CCI. Co‐administration of LiCl and Vit E synergistically reduced mechanical hyperalgesia in rats which were significantly different compared with the single administration of either Vit E or LiCl. Combined doses of Vit E and LiCl significantly increases the explorative behavior in the OFM. CCI increased malondialdehyde (MDA), tumor necrotic factor‐alpha (TNF‐α), calcitonin gene‐related polypeptide, calcium ion (Ca2+), and reduced superoxide dismutase (SOD) activities. Co‐administration of LiCl and Vit E significantly reduced MDA, TNF‐α, but increased SOD compared with ligated control. Discussion The findings revealed that the synergistic effects of the co‐administration of Vit E and LiCl in ameliorating NP are mediated by their anti‐inflammatory and antioxidant properties.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Effects of co‐administration of vitamin E and lithium chloride on chronic constriction injury‐induced neuropathy in male Wistar rats: Focus on antioxidant and anti‐inflammatory mechanisms

2021

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“…Lithium often reduces the attack frequency in CH, refs. [56][57][58] and it attenuated allodynia for heat, cold, and mechanical stimuli in animal experiments [59][60][61]. Finally, animal studies on CGRP receptor antagonists suggest an impact on hyperalgesia, as well [62].…”

Section: The Influence Of Prophylactic Treatmentmentioning

confidence: 87%

Cluster Headache Pathophysiology—A Disorder of Network Excitability?

Pohl

Sándor

Michels

et al. 2021

CTN

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Patients’ accounts of cluster headache attacks, ictal restlessness, and electrophysiological studies suggest that the pathophysiology involves Aδ-fibre nociceptors and the network processing their input. Continuous activity of the trigeminal autonomic reflex throughout the in-bout period results in central sensitization of these networks in many patients. It is likely that several factors force circadian rhythmicity upon the disease. In addition to sensitization, circadian changes in pain perception and autonomic innervation might influence the excitability of the trigeminal cervical complex. Summation of several factors influencing pain perception might render neurons vulnerable to spontaneous depolarization, particularly at the beginning of rapid drops of the pain threshold (“summation headache”). In light of studies suggesting an impairment of short-term synaptic plasticity in CH patients, we suggest that the physiologic basis of CH attacks might be network overactivity—similarly to epileptic seizures. Case reports documenting cluster-like attacks support the idea of distinct factors being transiently able to induce attacks and being relevant in the pathophysiology of the disorder. A sustained and recurring proneness to attacks likely requires changes in the activity of other structures among which the hypothalamus is the most probable candidate.

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