Lithium: mimicry, mania, and muscle relaxants

Flood, Simon; Bodenham, Andrew

doi:10.1093/bjaceaccp/mkq008

Cited by 2 publications

(3 citation statements)

References 4 publications

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“…As it is renally excreted, plasma lithium levels are sensitive to changes in patient's renal function and volume status. Medications that affect renal function, such as diuretics, angiotensinconverting enzyme inhibitors, and non-steroidal anti-inflammatory drugs, can increase lithium concentration and lead to toxicity [63]. For these reasons, caution must be taken pre-and postoperatively to monitor patient's volume status and renal function.…”

Section: Lithiummentioning

confidence: 99%

“…For anesthesia purposes, administration of lithium prolongs depolarization and polarization phase of neuromuscular blockade by acting additively with depolarizing neuromuscular agents and synergistically with non-depolarizing neuromuscular agents. [63] As a result, it can prolong neuromuscular blockade [64,65]. As a precaution, all patients treated with lithium undergoing neuromuscular blockage should be monitored appropriately.…”

Section: Lithiummentioning

confidence: 99%

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Anesthetic Concerns in Psychiatric Disease

Martinez-Baladejo¹,

Liongson²,

Wong³

et al. 2023

Updates in Anesthesia - The Operating Room and Beyond

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As the prevalence of mental health illnesses rises worldwide, the use of psychotropic medications follows. Undoubtedly, many patients using psychotropic medications will undergo procedures requiring anesthesia both in the operating room and outside of it. This chapter focuses on psychotropic medications that may complicate the surgical and postoperative course of patients undergoing anesthesia. Toward this aim, we performed a literature review using targeted key terms. Relevant articles were cited, and findings are summarized in this narrative review. We begin with discussing psychotropic medication pharmacology, drug-drug interactions, and side effects, emphasizing their interaction with anesthetic agents. We summarize the current recommendations for managing these medications in the perioperative period. In the discussion section, we focus on highlighting future directions for the intersection between psychotropic medications and anesthesia. Overall, we provide insight into the perioperative management of patients taking psychotropic medications, the point of intersection between the fields of psychiatry and anesthesia.

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Section: Lithiummentioning

confidence: 99%

Section: Lithiummentioning

confidence: 99%

Anesthetic Concerns in Psychiatric Disease

Martinez-Baladejo¹,

Liongson²,

Wong³

et al. 2023

Updates in Anesthesia - The Operating Room and Beyond

View full text Add to dashboard Cite

show abstract

“…Lithium prolongs the duration of action of both depolarizing (it has an additive effect with suxamethonium) and nondepolarizing neuromuscular blockers (synergistic effect). Neuromuscular monitoring is recommended in all patients receiving neuromuscular blockers [8].…”

Section: Mood Stabilizersmentioning

confidence: 99%

Perioperative management considerations in patients taking prescribed psychoactive medications (including those for depression and Parkinson's disease)

Wong

2021

Current Opinion in Anaesthesiology

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Purpose of reviewGiven the number of drugs available in the anaesthetist's armamentarium, drug interactions need to be managed. This is particularly true of psychoactive medications which primarily act on the central nervous system, targeting neurotransmitter pathways often affected by anaesthetic agents. This review gives an overview of the potential interactions of commonly used psychoactive medications with anaesthetic agents and hence their perioperative considerations. As anaesthetists will already be very familiar with the benzodiazepines, they will not be discussed here. Electroconvulsive therapy will also not be discussed. Recent findingsA wide range of psychoactive medications can interact with drugs commonly used in perioperative care including anaesthetic agents. There is limited clinical research into their effects and hence these interactions are based on known pharmacological actions. SummaryA cautious, pragmatic approach is recommended when managing patients on psychoactive medications requiring anaesthesia as part of their medical care.

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Lithium: mimicry, mania, and muscle relaxants

Cited by 2 publications

References 4 publications

Anesthetic Concerns in Psychiatric Disease

Anesthetic Concerns in Psychiatric Disease

Perioperative management considerations in patients taking prescribed psychoactive medications (including those for depression and Parkinson's disease)

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