“…Whether a substance was considered psychiatric or somatic co-medication was dependent on the respective indication/diagnosis. Risk medication, that is medication which increases the risk for lithium intoxication, includes thiazide (Ward, Musa et al 1994, Finley, Warner et al 1995, Berkowitz 2001) and loop diuretics (Okusa and Crystal 1994, Finley, Warner et al 1995, Oakley, Whyte et al 2001, Nunes 2018, ACE inhibitors (Finley, Warner et al 1995, Finley, O'Brien et al 1996, Nunes 2018, ARBs (Su, Chang et al 2007, Hayashi, Nishida et al 2016, Nagamine 2020, and NSAIDs (Okusa and Crystal 1994, Ward, Musa et al 1994, Oakley, Whyte et al 2001). While there are limited studies investigating the impact of ARB on lithium clearance, their pharmacodynamic similarity to ACE inhibitors, combined with the well-established link between ACE inhibitors and an increased risk of lithium intoxication (Finley et al, 1995(Finley et al, , 1996Juurlink et al, 2004), led us to include ARB in the risk medication category.…”