Lithium induced oxidative damage and inflammation in the rat’s heart: Protective effect of grape seed and skin extract

Mezni, Ali; Aoua, Hanène; Khazri, Olfa; Limam, Férid

doi:10.1016/j.biopha.2017.09.027

Cited by 34 publications

(26 citation statements)

References 49 publications

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“…Conflicting results have been obtained in a variety of studies on the antioxidant effect of treatments based on typical and atypical antipsychotics and lithium, and how they regulate oxidative stress in preclinical studies (18,19,(35)(36)(37)(38)(39). In our study, an increase in oxidative stress levels and a decrease in antioxidant response were noted in the two groups at 6 months, regardless of the medication administered.…”

Section: Discussioncontrasting

confidence: 60%

Association between medication adherence and oxidative stress in patients with first-episode mania

González‐Pinto¹,

Fernández²

2019

Preprint

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Poor adherence is a major problem in patients with manic episodes that impairs functionality and has unknown effects on oxidative stress. The objective of this study was to analyze the relationship between adherence to medication, severity of symptoms and oxidative stress in a sample of patients with a first episode of mania. A longitudinal, 6-month study was performed in 60 patients, who were classified as adherent and non-adherent to medication (mainly antipsychotics). Blood levels of oxidative stress parameters and expression of the antioxidant nuclear transcription factor NRF2 in mononuclear cells of peripheral blood were assessed at baseline and at the end of follow-up. In addition, clinical symptoms and functioning were evaluated. Linear multivariate regression was used to determine the relationship between adherence, oxidative stress, and clinical symptoms. Finally, 44 patients completed follow-up. The results of this study showed that at 6-month follow-up, adherence was significantly associated with better functioning and reduced clinical symptoms. Additionally, more severe symptoms were associated with increased levels of oxidative stress and antioxidant parameters. At study completion, non-adherents exhibited greater levels of antioxidants than adherent patients. In conclusion, poor adherence to medication is associated with a poorer prognosis in the medium term and causes increased antioxidant response.

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Section: Discussioncontrasting

confidence: 60%

Association between medication adherence and oxidative stress in patients with first-episode mania

González‐Pinto¹,

Fernández²

2019

Preprint

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“…In peripheral blood monocytes, lithium can increase the release of IL‐1β ( Kucharz, Sierakowski, Staite, & Goodwin, ). In parallel, Mezni et al () depicted that lithium can elevate the IL‐6 (pro‐inflammatory cytokine) level, causing inflammation and oxidative dysgenesis. In disagreement with our data, Li 2 CO 3 was found to cause a reduction in the level of IL‐1β (Albayrak et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…Lithium potentiates immunoglobulin levels and leukocytosis and alters the level of neutrophils (Maddu & Raghavendra, 2015). In addition, lithium can disrupt the levels of Tumor necrosis factor-alpha (TNF-α) and Interleukin-1 beta (IL-1β) (El-Twab & Abdul-Hamid, 2016;Freland and Beaulieu, 2012;Mezni, Aoua, Khazri, Limam, & Aouani, 2017) and Interferon-gamma (INF-γ) (Maes et al, 1999;Rapaport & Manji, 2001;Wang et al, 2013). Alternatively, LiCl exposure has been accompanied by diminished release of transforming growth factor-beta (TGFβ) (Chung, Sohn, Kwon, Jung, & Lee, 2014).…”

Section: Introductionmentioning

confidence: 99%

Maternal lithium chloride exposure alters the neuroendocrine‐cytokine axis in neonatal albino rats

Mohammed

Ahmed

2020

Intl J of Devlp Neuroscience

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The aim of this work was to clarify whether maternal lithium chloride (LiCl) exposure disrupts the neonatal neuroendocrine‐cytokine axis. Pregnant Wistar rats were orally administrated 50 mg LiCl/kg b.wt. from gestational day (GD) 1 to postpartum day 28. Maternal administration of LiCl induced a hypothyroid state in both dams and their neonates compared to the control dams and neonates at lactation days (LDs) 14, 21 and 28, where the levels of serum free triiodothyronine (FT3) and free thyroxin (FT4) were decreased and the level of serum thyrotropin (TSH) level was increased. A noticeable depression in maternal body weight gain, neonatal body weight and neonatal serum growth hormone (GH) was observed on all examined postnatal days (PNDs; 14, 21 and 28). A single abortion case was recorded at GD 17, and three dead neonates were noted at birth in the LiCl‐treated group. Maternal administration of LiCl disturbed the levels of neonatal serum tumor necrosis factor‐alpha (TNF‐α), transforming growth factor‐beta (TGF‐β), interleukin‐1 beta (IL‐1β), interferon‐gamma (INF‐γ), leptin, adiponectin and resistin at all tested PNDs compared to the control group. This administration produced a stimulatory action on the level of neonatal cerebral serotonin (5‐HT) at PND 14 and on the level of neonatal cerebral norepinephrine (NE) at PNDs 21 and 28. However, this administration produced an inhibitory action on the level of neonatal cerebral dopamine (DA) at all examined PNDs and on the level of neonatal cerebral NE at PND 14 and the level of neonatal cerebral 5‐HT at PNDs 21 and 28 compared to the corresponding control group. Thus, maternal LiCl exposure‐induced hypothyroidism disrupts the neonatal neuroendocrine‐cytokine system, which delay cerebral development.

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“…Study demonstrated that Li (2,5, or 100 mg of lithium chloride/kg, i.p.) aggravated an expanded oxidative stress status, proven by high lipoperoxidation and protein carbonylation, with a low non protein thiols level and influenced antioxidant enzymes as CAT, Gpx and SOD (Mezni et al, 2017).…”

Section: Lithiummentioning

confidence: 99%

A conglomeration of preclinical models related to myocardial infarction

Ahsan

Mahmood

Usmani

et al. 2020

Braz. J. Pharm. Sci.

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Cardiovascular diseases are the main source of death and morbidity in developed and developing nations. Animal models are required to propel our understanding of the pathogenesis, increase our knowledge, disease progress, and mechanism behind cardiovascular disorder, providing new approaches focused to improve the diagnostic and the treatment of these pathological conditions and additionally to test various therapeutic ways to deal with tissue regeneration and re-establish heart working following damage. A perfect model framework ought to be reasonable, effectively controlled, reproducible, and physiologically illustrative of human disease, show cardinal signs and pathology that resembles after the human ailment and ethically stable. The decision of selection of animal model should be considered precisely since it influences exploratory results and whether results of the research can be sensibly matched with the human. In this way, no specific technique splendidly reproduces the human disease, and relying upon the model, extra cost burden, resources, infrastructure and the necessity for technical hands, should also be kept under consideration. Here we have discussed and compiled various methods of inducing myocardial infarction in animals, basically by surgery, chemicals and through genetic modification, this may benefit the researchers in getting a complied data regarding various methods through which they can induce myocardial infarction in animals.

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Lithium induced oxidative damage and inflammation in the rat’s heart: Protective effect of grape seed and skin extract

Cited by 34 publications

References 49 publications

Association between medication adherence and oxidative stress in patients with first-episode mania

Association between medication adherence and oxidative stress in patients with first-episode mania

Maternal lithium chloride exposure alters the neuroendocrine‐cytokine axis in neonatal albino rats

A conglomeration of preclinical models related to myocardial infarction

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