Lithium effects on position learning with exploratory and aversive goal-box conditions

Hines, Garth

doi:10.1016/0091-3057(85)90515-5

Cited by 11 publications

(6 citation statements)

References 18 publications

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“…Subchronic lithium reportedly delayed acquisition of conditioned fear, in a way analogous to the delay noted if stimulus salience is decreased by detailed exploration of the apparatus before initiation of conditioning (Cappeliez and Moore 1988). In line with this study, rats under chronic lithium showed impaired acquisition of an exploration- Gallo et al 1990 ↑ improved performance in lithium-treated subjects compared to controls, ↓ compromised performance in lithium-treated subjects compared to controls, Ǿ unaffected performance in lithium-treated subjects compared to controls reinforced position discrimination under conflict (Hines 1985) and delayed acquisition of passive avoidance (Hines and Poling 1984). However, in more recent studies, subchronic and chronic lithium treatment reportedly improved passive avoidance acquisition (Pascual and Gonzalez 1995;Tsaltas et al 2007a) and did not affect fear conditioning (Tsaltas et al 2007b).…”

Section: Animal Studiessupporting

confidence: 71%

Lithium and cognitive enhancement: leave it or take it?

et al. 2008

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Section: Animal Studiessupporting

confidence: 71%

Lithium and cognitive enhancement: leave it or take it?

et al. 2008

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“…Moreover, lithium effects on the acquisition of appetitive behaviours could also be related to a reduction in stress-induced cognitive deficits. Reports on the cognitive effects of lithium in humans (Ananth et al, 1987 ;Pachet and Wisniewski, 2003 ;O'Donnell and Gould, 2007) and animals (Hines and Poling, 1984 ;Hines, 1985Hines, , 1986Cappeliez et al, 1989 ;Gallo et al, 1990 ;Pascual and Gonzalez, 1995 ;Nocjar et al, 2007 ;O'Donnell and Gould, 2007 ;Tsaltas et al, 2007a, b) are inconsistent. However, the finding that repeated lithium administration restores the analgesic effect associated with sweet taste pre-exposure, which had previously been abolished by chronic variable stress, led to the conclusion that lithium may counteract stress-induced anhedonia (Vasconcellos et al, 2006).…”

Section: Discussionmentioning

confidence: 95%

Anti-anhedonic activity of long-term lithium treatment in rats exposed to repeated unavoidable stress

Marchese

Scheggi

Secci

et al. 2013

International Journal of Neuropsychopharmacology

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Behavioural and neurochemical responses to palatable food exposure represent an index of hedonic competence. In rats, a palatable meal increases extra-neuronal dopamine levels in the nucleus accumbens shell (NAcS) that confers to it incentive salience and reinforcing value. Repeated stress exposure decreases dopamine output and impairs the NAcS dopaminergic response to palatable food and the competence to acquire a vanilla sugar (VS)-reinforced instrumental behaviour [VS-sustained appetitive behaviour (VAB)]. Moreover, chronic stress exposure disrupts reactivity to aversive stimuli. A 3-wk treatment with lithium, the gold-standard treatment in bipolar disorder, tonically reduces NAcS dopamine output and the reactivity to aversive stimuli. However, it does not affect the dopaminergic response to VS and the competence to acquire VAB. This study investigated whether repeated lithium administration is endowed with anti-anhedonic activity. The NAcS dopaminergic response to VS and the competence to acquire VAB and sucrose self-administration (SA), in terms of fixed-ratio (FR)1, FR5 and progressive ratio schedules of reinforcement, were studied in saline or lithium-treated groups of non-food-deprived rats exposed or not to repeated unavoidable stress. Chronic stress exposure impaired the NAcS dopaminergic response to VS, acquisition of VAB and sucrose SA, in terms of FR1 and FR5 schedules of reinforcement and breaking point score. Repeated lithium treatment restored these parameters to control group values, even when treatment began in rats already showing an anhedonia-like condition. Since the breaking point defines the reinforcement efficacy of a hedonic stimulus, the present data suggest that lithium treatment is endowed with anti-anhedonic activity in rats.

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“…Six of subjects (Li) received lithium chloride (20 mEq/1) in their drinking water while the remaining six (TW) received tap water. This lithium drinking water concentration has been found to produce serum levels averaging 0.68 meq/1 (Hines 1985).…”

Section: Methodsmentioning

confidence: 99%

Lithium effects on adjunctive alcohol consumption in rats

Hines

Henslee

1986

Psychopharmacology

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Rats receiving chronic administration of lithium chloride (20 mEq/l) in their drinking water were tested for acquisition of adjunctive alcohol (10% v/v) consumption. Contrary to expectations, subjects receiving lithium acquired the adjunctive drinking more rapidly, and under less optimal conditions, than did control subjects. The high death rate in subjects receiving lithium while undergoing a concurrent alcohol withdrawal suggests that particular caution must be observed when lithium is used in the treatment of alcoholics.

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Lithium effects on position learning with exploratory and aversive goal-box conditions

Cited by 11 publications

References 18 publications

Lithium and cognitive enhancement: leave it or take it?

Lithium and cognitive enhancement: leave it or take it?

Anti-anhedonic activity of long-term lithium treatment in rats exposed to repeated unavoidable stress

Lithium effects on adjunctive alcohol consumption in rats

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