Lithium Effects on Magnesium Metabolism in Rats

Et, Mellerup; Plenge, Per; Oj, Rafaelsen

doi:10.1159/000467989

Cited by 16 publications

(6 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, Mellerup et al (1973) showed an increase in plasma magnesium after a single intraperitoneal injection of 900 ,umol of lithium chloride which is comparable to the increased magnesium level we obtained with a very different dosage and route of administration.…”

Section: Discussionsupporting

confidence: 86%

“…Comparing the results of the present study with those of Birch & Jenner (1973), both show a decrease in brain magnesium proportionally depending on the dose of lithium, although in the latter case lithium was administered by intraperitoneal injection or in the drinking water. Also, Mellerup et al (1973) showed an increase in plasma magnesium after a single intraperitoneal injection of 900 ,umol of lithium chloride which is comparable to the increased magnesium level we obtained with a very different dosage and route of administration.…”

Section: Discussionsupporting

confidence: 86%

See 1 more Smart Citation

The Distribution of Lithium, Sodium and Magnesium in Rat Brain and Plasma After Various Periods of Administration of Lithium in the Diet

Bond

Brooks²,

Judd³

1975

British J Pharmacology

View full text Add to dashboard Cite

1The tissue solubilizer Soluene-100 provides an efficient and easy means of preparing small amounts of rat tissue for cation analysis. 2 Administration of lithium ions to rats for two days to 42 days by the addition of lithium chloride to the diet at a concentration of 30 mmol/kg dry weight results in (a) the uniform distribution of lithium throughout the brain at a concentration comparable to that found in plasma; (b) decrease in the brain sodium concentration; (c) a decrease in brain magnesium concentration and an increase in plasma magnesium concentration; (d) no change in brain water content.3 The inclusion of LiCl in the diet at a concentration of 30 mmol/kg dry food gives consistent and predictable plasma and brain levels of lithium in the rat without the occurrence of serious side effects over periods of up to 42 days.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 86%

The Distribution of Lithium, Sodium and Magnesium in Rat Brain and Plasma After Various Periods of Administration of Lithium in the Diet

Bond

Brooks²,

Judd³

1975

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…A number of reports have shown that lithium treatment is accompanied by increased plasma magnesium concentrations (Nielsen, 1964;Bunney, Goodwin, Davies & Fawcett, 1968;Aronoff et al 1971;Andreoli et al 1972;Birch & Jenner, 1973;Mellerup et al 1973). Birch & Jenner (1973) reported that in rats lithium apparently leads to a reduction in brain magnesium at the same time that plasma magnesium levels are increased.…”

Section: Discussionmentioning

confidence: 99%

“…Baer, Kassir & Fieve (1970) ;Ho, Gershon & Pinckney (1970); and Birch & Jenner (1973) found that chronic administration of lithium to rats results in a significant decrease in brain sodium concentration. An increase in serum magnesium concentration has also been observed to accompany treatment with lithium (Nielsen, 1964;Aronoff et al (1971); and Andreoli, Villani & Brambilla, 1972;Mellerup, Plenge & Rafaelsen, 1973;and Birch & Jenner, 1973). Therefore, the effect of lithium on the metabolism of electrolytes in the C.N.S.…”

Section: Introductionmentioning

confidence: 98%

The effect of lithium on electrolyte transport by the in situ choroid plexus of the cat.

Reed¹,

Yen²

1980

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. The effects of lithium on electrolyte transport were studied by using the cat choroid plexus isolated in a chamber in situ.2. Lithium infused intravenously to produce plasma lithium concentrations up to 5 m-equiv/l. caused an increase in plasma magnesium with no effect on the concentration of magnesium in the chamber fluid.3. When 22NaCl was infused intravenously the chamber fluid/plasma ratio of 22Na was nearly 1 in the first 30 min sample and at the steady state it was significantly greater than 1.4. When lithium chloride (1-5 m-equiv/l.) or potassium chloride (6.6 m-equiv/l.) was added to the chamber at the start of a collection period with plasma 22Na in the steady state, the 22Na content of the chamber fluid promptly increased 118 and 68 %, respectively, above the control value with no increase in secretary rate.5. The addition of ouabain to the chamber fluid, in addition to the lithium chloride or potassium chloride, tended to stimulate or have no significant effect on 22Na uptake at a concentration of 10-5 M and to reduce it as well as the secretary rate at 10-3 M.6. The data are compatible with there being two functionally separate sodium transport systems in the choroid plexus. One transports sodium accompanied by an anion and water to provide the fluid secreted into the chamber (c.s.f.) and the other operates primarily to regulate the potassium concentration of the c.s.f. by pumping potassium out in exchange for sodium.7. Lithium can be transported by both systems to a limited extent and the presence of lithium in the c.s.f. stimulates the sodium-potassium regulating pump.

show abstract

“…The results concerning the effect of lithium on calcium and magnesium metabolism seem conflicting. Some groups have found an increase in serum calcium (Mellerup et al (1970(Mellerup et al ( , 1973, Andreoli et al (1972), Birch & Jenner (1973), Christiansen et al (1975a) and serum magnesium ( Nielsen (1964), Aronofl et al (1971( ), Christiansen et al (1975a, Transbll et al (1977)) during lithium treatment, while others have failed to confirm these changes (Tupin et al (1968), Hennernann & Zimmerberg (1974). None of these reports has taken into consideration the unipolar/bipolar distinction.…”

Section: Leonhard'smentioning

confidence: 98%

Calcium metabolism in lithium‐treated patients

Baastrup

Transbøl

1978

Acta Psychiatr Scand

View full text Add to dashboard Cite

The bone mineral content (BMC) together with biochemical indices of calcium metabolism were measured in 83 manic-depressive patients on long-term lithium therapy. The patients were diagnosed and divided into a unipolar and a bipolar group according to strict symptomatic course criteria. The patients with bipolar course had a significantly decreased BMC (88% of normal, P is less than 0.001), while the unipolar patients had normal BMC. Both groups had biochemical changes consistent with primary hyperparathyroidism.

show abstract

Lithium Effects on Magnesium Metabolism in Rats

Cited by 16 publications

References 15 publications

The Distribution of Lithium, Sodium and Magnesium in Rat Brain and Plasma After Various Periods of Administration of Lithium in the Diet

The Distribution of Lithium, Sodium and Magnesium in Rat Brain and Plasma After Various Periods of Administration of Lithium in the Diet

The effect of lithium on electrolyte transport by the in situ choroid plexus of the cat.

Calcium metabolism in lithium‐treated patients

Contact Info

Product

Resources

About