Lithium Dichloro(1-methylethyl)-magnesate

Knöchel, Paul; Gavryushin, Andrei

doi:10.1002/047084289x.rn01161

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Cited by 2 publications

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References 19 publications

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“…Known for decades for impacting the reactivity of organolithium and organomagnesium derivatives, this salt has a multitude of other important effects . For instance, LiCl improves the solubility of less soluble lithium derivatives and is also critical for attaining efficient metalation processes, including useful levels of both enantioselectivity in deprotonations with chiral lithium amides and chemoselectivity of turbo-Grignard reagents …”

Section: Introductionmentioning

confidence: 99%

A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl

et al. 2015

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Section: Introductionmentioning

confidence: 99%

A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl

et al. 2015

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Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides

Berton

Sheehan

Adamo

et al. 2020

Beilstein J. Org. Chem.

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Magnesium organometallic reagents occupy a central position in organic synthesis. The freshness of these compounds is the key for achieving a high conversion and reproducible results. Common methods for the synthesis of Grignard reagents from metallic magnesium present safety issues and exhibit a batch-to-batch variability. Tubular reactors of solid reagents combined with solution-phase reagents enable the continuous-flow preparation of organomagnesium reagents. The use of stratified packed-bed columns of magnesium metal and lithium chloride for the synthesis of highly concentrated turbo Grignards is reported. A low-cost pod-style synthesizer prototype, which incorporates single-use prepacked perfluorinated cartridges and bags of reagents for the automated on-demand lab-scale synthesis of carbon, nitrogen, and oxygen turbo magnesium bases is presented. This concept will provide access to fresh organomagnesium reagents on a discovery scale and will do so independent from the operator’s experience in flow and/or organometallic chemistry.

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Lithium Dichloro(1-methylethyl)-magnesate

Cited by 2 publications

References 19 publications

A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl

A Lithium Amide Protected Against Protonation in the Gas Phase: Unexpected Effect of LiCl

Disposable cartridge concept for the on-demand synthesis of turbo Grignards, Knochel–Hauser amides, and magnesium alkoxides

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