Lithium counteracts carbamazepine-induced leukopenia while increasing its therapeutic effect

Brewerton, Timothy D.

doi:10.1016/0006-3223(86)90130-7

Cited by 26 publications

(3 citation statements)

References 46 publications

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“…Also, in a prospective study (15) of 14 patients with lithium-resistant bipolar disorder, treatment with the combination of lithium and carbamazepine for 1 year was superior to treatment with lithium and neuroleptics in the nine patients completing the study. Several other anecdotal reports (16)(17)(18)(19) suggest that the combination of lithium and carbamazepine is effective and perhaps synergistic. Besides efficacy, another advantage noted in the literature is that lithium may counteract carbamazepine-induced leukopenia, although the clinical significance of this phenomenon is unclear (19)(20)(21).…”

Section: Combinations With Lithiummentioning

confidence: 96%

Mood Stabilizer Combinations: A Review of Safety and Efficacy

Freeman

Stoll²

1998

AJP

185

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There have been few controlled studies of the use of combinations of mood stabilizers. The interactions of such combinations are sometimes complex, often very useful, and potentially dangerous. One general rule that may reduce the risks of toxic drug interactions is to add medication to the patient's current regimen in modest doses and increase the dose slowly. The safest and most efficacious mood stabilizer combinations appear to be the mixtures of anticonvulsants and lithium, particularly valproate plus lithium. Once the mechanisms of the mood stabilizers are identified, it is possible that a more rational approach to combination therapy will emerge, based on synergism at the sites of action.

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Section: Combinations With Lithiummentioning

confidence: 96%

Mood Stabilizer Combinations: A Review of Safety and Efficacy

Freeman

Stoll²

1998

AJP

185

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“…Co-administration of lithium and carbamazepine has been suggested in patients with suspected carbamazepine-induced neutropenia, and in those who have bipolar disorder unresponsive to lithium alone (Brewerton, 1986;Vieweg et al, 1986).…”

Section: Other Psychoactive Drugs and Leucopeniamentioning

confidence: 99%

Haematological toxicity of drugs used in psychiatry

Flanagan

Dunk

2007

Hum. Psychopharmacol. Clin. Exp.

193

154

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“…However, our finding is consistent with that of a previous study, which showed identical serum lithium levels in patients treated with once-and twice-daily regimens (24). Leukocytosis, a frequent hematological abnormality in patients on lithium, is generally benign and has actually been used in treating some conditions associated with depressed granulocytes Davis et al (26) reported that lithium had generally been considered to raise the serum calcium level and produce a drug-dependent, reversible bio- (25). chemical hyperparathyroidism.…”

Section: A Recent Double-blind Study By Muir Et Al Observed No Sigmentioning

confidence: 99%

Lithium treatment: a comparison of once‐and twice‐daily dosing

Abraham

Delva

Waldron

et al. 1992

Acta Psychiatr Scand

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The effects of once- and twice-daily dosing with lithium carbonate were compared in a non-blind, cross-over study on 20 consecutive patients with mood disorders. Mental status, side effects and target organ function were examined after a minimum of a 1-month treatment with each regimen. Eighteen patients completed the study and 2 withdrew because of side effects. There were no significant differences between the 2 groups on the Hamilton Rating Scale for Depression, the Bech-Rafaelsen Mania Scale, the UKU Side Effects Scale or in serum lithium, electrocardiogram and urine volumes. Most blood tests showed no significant difference between the 2 treatment schedules except for white blood cells, ionized calcium and phosphate concentration. The once-daily regimen was associated with a higher white cell count, increased serum phosphate and elevated serum ionized calcium. We conclude that patients are able to tolerate once-daily dosing with lithium carbonate as well as twice-daily dosing.

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Lithium counteracts carbamazepine-induced leukopenia while increasing its therapeutic effect

Cited by 26 publications

References 46 publications

Mood Stabilizer Combinations: A Review of Safety and Efficacy

Mood Stabilizer Combinations: A Review of Safety and Efficacy

Haematological toxicity of drugs used in psychiatry

Lithium treatment: a comparison of once‐and twice‐daily dosing

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