Lithium chloride improves bone filling around implants placed in estrogen-deficient rats

Enhanced osteogenic differentiation of mesenchymal stem cells by surface lithium modification in a sandblasted/acid-etched titanium implant

“…12,13 LiCl treatment increases GSK-3β phosphorylation at Ser9 and stabilizes cytoplasmic β-catenin, which in turn facilitates translocation of soluble β-catenin into the nucleus and triggers osteogenesis-related signaling cascades. 12,18 In this study, we asked if surface Li modification would also exert an effect of Li salt acting as a GSK-3β inhibitor. This has been documented in cell culture experiments when LiCl was added to the cell culture media.…”

“…15–17 Incubation of mesenchymal stem cells (MSCs) or osteoblastic cells with Li salt promotes osteoblastic differentiation 12,18 and systemic administration of LiCl enhances the bone filling around Ti screws in the tibia of ovariectomized rats. 18…”

“…12,13,15 The β-catenin stabilization and subsequent translocation of soluble β-catenin into the nucleus activates the transcription of target genes related to osteogenesis, 1 such as Runx2 and osterix, by interacting with T-cell factor/ lymphoid enhancer factor (TCF/LEF) family, which then promotes osteogenic differentiation of osteoprogenitor cells. [15][16][17] Incubation of mesenchymal stem cells (MSCs) or osteoblastic cells with Li salt promotes osteoblastic differentiation 12,18 and systemic administration of LiCl enhances the bone filling around Ti screws in the tibia of ovariectomized rats. 18 However, there are only very limited studies yet reported on the beneficial osteogenic effect of Li ions when directly incorporated into the solid surface of clinical Ti implants.…”

“…[15][16][17] Incubation of mesenchymal stem cells (MSCs) or osteoblastic cells with Li salt promotes osteoblastic differentiation 12,18 and systemic administration of LiCl enhances the bone filling around Ti screws in the tibia of ovariectomized rats. 18 However, there are only very limited studies yet reported on the beneficial osteogenic effect of Li ions when directly incorporated into the solid surface of clinical Ti implants. 10 Studies have reported the beneficial effect of Li treatment of the Ti surfaces.…”

Lithium Chloride rescues Monensin-potentiated Wnt signaling inhibition in inflammatory bone loss in rats

“…Monensin (Mon), in the other hand, is a natural compound isolated from Streptomyces cinnamonensis and belongs to the group of ionophore antibiotics that bind to cations such as Na+, K + and Li+. Mon exhibits a broad spectrum of biological activities such as antimicrobial, antiproliferative, antiparasitic and antiviral [12]. However, more recently, Monensin has been studied as a drug with anti-cancer activity 12 , showing positive effect both in vitro and in vivo against melanoma cells [13], leukemia acute myeloid [14] and prostate cancer [15].…”