Lithium bidirectionally regulates depression- and mania-related brain functional alterations without worsening cognitive function in patients with bipolar disorder

Zhuo, Chuanjun; Chen, Guangdong; Chen, Jiayue; Tian, Hongjun; Ma, Xiaoyan; Li, Qianchen; Yang, Lei; Zhang, Qiuyu; Li, Ranli; Song, Xueqin; Huang, Chunhai

doi:10.3389/fpsyt.2022.963005

Cited by 1 publication

(1 citation statement)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, lithium is used as a mood-stabilizing drug (Baldessarini 2013) and affects mood disorders i.e. suppressing mania and depression (Zhuo et al 2022). However, significant neurocognitive and behavioral adverse effects often occur, due to its' narrow therapeutic index.…”

Section: Introductionmentioning

confidence: 99%

Impact of chronic lithium treatment on brain oxidative stress and anxiety-like behaviors in rats: Dose-dependent effects

Eraslan,

Matur,

Akyol

et al. 2024

gpb

View full text Add to dashboard Cite

Lithium (Li) is a mood-stabilizing drug. Although one of the potential mechanisms underlying the neuroprotective effects of lithium is related to its antioxidative effect, its mechanisms of action are not fully understood. Herein we aimed to investigate the impact of varied dosages of long-term lithium therapy on oxidative stress parameters in the brains of healthy rats, and on anxiety-like behaviors, and whether any changes in behavior can be attributed to modifications in oxidative stress levels within the brain. Thirty-two adult Wistar albino male rats were randomly assigned to four treatment groups. While the control (C) group was fed with a standard diet, low Li (1.4 g/kg/diet), moderate Li (1.8 g/kg/diet), and high Li (2.2 g/kg/diet) groups were fed with lithium bicarbonate (Li 2 CO 3 ) for 30 days. Malondialdehyde increased, while superoxide dismutase and catalase levels decreased in the brains of the high Li group animals. In addition, anxiety-like behaviors of animals increased in the high Li group considering fewer entries to and less time spent in the open arms of the elevated plus maze test. Our findings underscore the potential adverse effects of prolonged lithium treatment, especially at doses approaching the upper therapeutic range. The induction of toxicity, manifested through heightened oxidative stress, appears to be a key mechanism contributing to the observed increase in anxiety-like behaviors. Consequently, caution is warranted when considering extended lithium therapy at higher doses, emphasizing the need for further research to delineate the precise mechanisms underlying these effects and to inform safer therapeutic practices.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of chronic lithium treatment on brain oxidative stress and anxiety-like behaviors in rats: Dose-dependent effects

Eraslan,

Matur,

Akyol

et al. 2024

gpb

View full text Add to dashboard Cite

show abstract

Lithium bidirectionally regulates depression- and mania-related brain functional alterations without worsening cognitive function in patients with bipolar disorder

Abstract: Song X and Huang C () Lithium bidirectionally regulates depression-and mania-related brain functional alterations without worsening cognitive function in patients with bipolar disorder.

Cited by 1 publication

References 58 publications

Impact of chronic lithium treatment on brain oxidative stress and anxiety-like behaviors in rats: Dose-dependent effects

Impact of chronic lithium treatment on brain oxidative stress and anxiety-like behaviors in rats: Dose-dependent effects

Contact Info

Product

Resources

About