Lithium Acne

Okrasinski, Henrik

doi:10.1159/000251073

Cited by 20 publications

(4 citation statements)

References 4 publications

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“…Calloway 29 reported pruritic maculopapular eruptions and pre‐tibial ulcerations in some patients receiving lithium. Others have shown lithium related folliculitis, 30 ac‐neform eruptions, 31,32 seborrheic dermatitis, and palmoplantar hyperkeratosis 33…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Psoriasis: A Review Including a Case Report of Dermabrasion of Hypertrophic Psoriatic Plaques

Gold

Roenigk

1987

The Journal of Dermatologic Surgery and Oncology

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Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Psoriasis: A Review Including a Case Report of Dermabrasion of Hypertrophic Psoriatic Plaques

Gold

Roenigk

1987

The Journal of Dermatologic Surgery and Oncology

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“…Long-term lithium therapy has been shown to suppress neuronal p53 levels [259,260] and reduces the transcriptional activity of FoxO3 by decreasing its intracellular content [261]. Intriguingly, acne is a possible adverse effect of lithium therapy [262][263][264], a potential result of attenuated p53/FoxO signaling. Remarkably, the treatment of mice with isotretinoin results in both decreased hippocampal neurogenesis and a reduction in hippocampal volume [265,266].…”

Section: Depression and Impaired Hippocampal Neurogenesismentioning

confidence: 99%

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment

Melnik

2023

Cells

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This review on acne transcriptomics allows for deeper insights into the pathogenesis of acne and isotretinoin’s mode of action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin and androgen signaling activate the kinase AKT and mechanistic target of rapamycin complex 1 (mTORC1). A Western diet (hyperglycemic carbohydrates and milk/dairy products) also co-stimulates AKT/mTORC1 signaling. The AKT-mediated phosphorylation of nuclear FoxO1 and FoxO3 results in their extrusion into the cytoplasm, a critical switch which enhances the transactivation of lipogenic and proinflammatory transcription factors, including androgen receptor (AR), sterol regulatory element-binding transcription factor 1 (SREBF1), peroxisome proliferator-activated receptor γ (PPARγ) and signal transducer and activator of transcription 3 (STAT3), but reduces the FoxO1-dependent expression of GATA binding protein 6 (GATA6), the key transcription factor for infundibular keratinocyte homeostasis. The AKT-mediated phosphorylation of the p53-binding protein MDM2 promotes the degradation of p53. In contrast, isotretinoin enhances the expression of p53, FoxO1 and FoxO3 in the sebaceous glands of acne patients. The overexpression of these proapoptotic transcription factors explains isotretinoin’s desirable sebum-suppressive effect via the induction of sebocyte apoptosis and the depletion of BLIMP1(+) sebocyte progenitor cells; it also explains its adverse effects, including teratogenicity (neural crest cell apoptosis), a reduced ovarian reserve (granulosa cell apoptosis), the risk of depression (the apoptosis of hypothalamic neurons), VLDL hyperlipidemia, intracranial hypertension and dry skin.

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“…Tetracycline and its derivatives must be avoided because of increasing lithium levels and concomitant nephrotoxicity 32 . Sometimes reductions/adjustments in dose, or discontinuation, may be required in recalcitrant cases 33–35 …”

Section: Dermatologic Manifestationsmentioning

confidence: 99%

“…32 Sometimes reductions/ adjustments in dose, or discontinuation, may be required in recalcitrant cases. [33][34][35]…”

Section: Acne and Acneiform Eruptionmentioning

confidence: 99%

Lithium and skin: dermatologic manifestations of lithium therapy

Jafferany

2008

Int J Dermatology

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Lithium Acne

Abstract: A young woman aged 21 developed acne eruption after 3 weeks treatment with lithium carbonate.

Cited by 20 publications

References 4 publications

Surgical Treatment of Psoriasis: A Review Including a Case Report of Dermabrasion of Hypertrophic Psoriatic Plaques

Surgical Treatment of Psoriasis: A Review Including a Case Report of Dermabrasion of Hypertrophic Psoriatic Plaques

Acne Transcriptomics: Fundamentals of Acne Pathogenesis and Isotretinoin Treatment

Lithium and skin: dermatologic manifestations of lithium therapy

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