Lithiation of 1H-pyrazolo[3,4-d]pyrimidine derivative using lithium alkanetellurolate

Preparation of Nitrogen-Containing π-Deficient Heteroaromatic Grignard Reagents: Oxidative Magnesiation of Nitrogen-Containing π-Deficient Halogenoheteroaromatics Using Active Magnesium

“…2,2-Dimethyl-1-(1-phenyl-1 H -pyrazolo[3,4- d ]pyrimidin-4-yl)-1-propanol , was purified with silica gel chromatography (eluted with hexanes−ethyl acetate (3:1)) as pale yellow solids. Mp 115 °C (lit.…”

Preparation and characterization of symmetrical bis[4-chloro-2-pyrimidyl] dichalcogenide (S, Se, Te) and unsymmetrical 4-chloro-2-(arylchalcogenyl) pyrimidine: X-ray crystal structure of 4-chloro-2-(phenylselanyl) pyrimidine and 2-(p-tolylselanyl)-4-chloropyrimidine

“…Jerchel et al [29] were the first to synthesize bis(4-pyridyl) diselenide and bis(4-pyridyl) selenide by reacting N-pyridyl (4-pyridinium) chloride with hydrogen selenide. Tanji et al [30] reported the formation of alkyl pyridyl telluride by reacting bromopyridine with lithium alkyltellurolate. Recently, Bhasin and Singh [31] prepared various methyl-substituted bis(2-pyridyl) dichalcogenides (Se, Te) by using hydrazine hydrate as a reducing agent in basic medium using DMF as a solvent.…”

Synthesis of Substituted Quinazolin-4(3H)-ones and Quinazolines via Directed Lithiation

“…The use of directing groups to facilitate lithiation followed by reaction of the organolithium reagents thus obtained with various electrophiles had found wide application in a variety of synthetic transformations. [2][3][4] In particular, the pivaloylamino group is useful for directed oath-lithiation of aromatic compounds and had been applied to pyridine derivatives. 5,6 However there are relatively few examples of the use of such groups for directed lithiation of more complicated heterocycles.…”