Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Riboflavin

Buijssen, M.; Eeuwijk, Jennifer; Noordegraaf‐Schouten, Marije Vonk

doi:10.2903/sp.efsa.2014.en-591

Cited by 3 publications

(4 citation statements)

References 52 publications

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“…Regarding their toxicity, as reported in the literature and already mentioned, we found that the liposoluble vitamins have the greatest risk of bioaccumulation (i.e., the highest toxicity) compared with hydrosoluble ones, although of these, vitamin B1, B2, B7 and B9 could have a higher risk of accumulation. At the moment, the present data regarding thiamine and riboflavin toxicity are inconsistent and the studies performed show a high risk of bias, as reported by several reviews [61][62][63].…”

Section: Discussionmentioning

confidence: 99%

Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

et al. 2021

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Background and Objectives: The present study demonstrates that apart from the well-known toxicity of liposoluble vitamins, some hydrosoluble vitamins may also exert toxicity; thus, routine supplementation with vitamins or ingestion of fortified foods should not be considered harmless. The study addresses the possible correlations between the physico-chemical properties and the side effects of vitamins when taken in high doses or for a too long a period. Materials and Methods: The FAFDrugs4.0 computational tool was used for computational assessment of the ADMET profile of several hydro- and liposoluble vitamins. Results: ADMET analysis revealed the following major data: vitamin B3 and B13 showed reduced structural complexity; thus, a relative toxicological potential may be exerted. Vitamins B1 and B7 were found to have good oral absorption and thus good bioavailability, while Vitamin B3 was found to have decreased oral absorption. In addition, all of the liposoluble vitamins reflected higher complexity, much greater than most of the potentially therapeutically-proven compounds. Conclusions: The present study emphasizes the importance between the physico-chemical properties of vitamins and their possible toxicological impact.

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Section: Discussionmentioning

confidence: 99%

Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

et al. 2021

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“…The Panel used a comprehensive search of the literature published from 1990 onwards as preparatory work to the present opinion in order to identify data on which DRVs for riboflavin may potentially be based (Buijssen et al., ), including data on breast milk concentration of ‘total flavin’ or total or free riboflavin (Ortega et al., ; Sakurai et al., ; Kodentsova and Vrzhesinskaya, ). The Panel also considered additional individual studies reviewed by the SCF () or by Bates and Prentice () and Picciano () on ‘total flavin’ or total or free riboflavin concentration in breast milk (Nail et al., ; Thomas et al., ; Ford et al., ; Dostálová et al., ; Roughead and McCormick, ).…”

Section: Definition/categorymentioning

confidence: 99%

“…The relationship between riboflavin intake and chronic disease outcomes has been investigated in trials, and also in observational studies where associations between intake and disease outcomes may be confounded by uncertainties inherent to the methodology used for the assessment of riboflavin intake and by the effect of dietary, lifestyle or other undefined factors on the disease outcomes investigated. A comprehensive search of the literature published between 1990 and 2014 was performed as preparatory work to this assessment in order to identify new data on relevant health outcomes upon which DRVs for riboflavin could be based (Buijssen et al., ). An additional literature search (in Pubmed) was performed to identify new data published until mid‐2016 on riboflavin intake and health outcomes.…”

Section: Criteria (Endpoints) On Which To Base Dietary Reference Valuesmentioning

confidence: 99%

Dietary Reference Values for riboflavin

Products¹,

Turck²,

Bresson³

et al. 2017

EFS2

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Following a request from the European Commission, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) derives dietary reference values (DRVs) for riboflavin. The Panel considers that the inflection point in the urinary riboflavin excretion curve in relation to riboflavin intake reflects body saturation and can be used as a biomarker of adequate riboflavin status. The Panel also considers that erythrocyte glutathione reductase activation coefficient is a useful biomarker, but has limitations. For adults, the Panel considers that average requirements (ARs) and population reference intakes (PRIs) can be determined from the weighted mean of riboflavin intake associated with the inflection point in the urinary riboflavin excretion curve reported in four intervention studies. PRIs are derived for adults and children assuming a coefficient of variation of 10%, in the absence of information on the variability in the requirement and to account for the potential effect of physical activity and the methylenetetrahydrofolate reductase 677TT genotype. For adults, the AR and PRI are set at 1.3 and 1.6 mg/day. For infants aged 7-11 months, an adequate intake of 0.4 mg/day is set by upward extrapolation from the riboflavin intake of exclusively breastfed infants aged 0-6 months. For children, ARs are derived by downward extrapolation from the adult AR, applying allometric scaling and growth factors and considering differences in reference body weight. For children of both sexes aged 1-17 years, ARs range between 0.5 and 1.4 mg/day, and PRIs between 0.6 and 1.6 mg/day. For pregnant or lactating women, additional requirements are considered, to account for fetal uptake and riboflavin accretion in the placenta during pregnancy or the losses through breast milk, and PRIs of 1.9 and 2.0 mg/day, respectively, are derived.

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“…Based on the title, 10 articles were picked up, of which three were considered relevant based on the full articles (6)(7)(8). In addition, official reports published by EFSA (1,9) and the Institute of Medicine (IOM) (10) were used, of which one was considered by the committee as a qualified systematic review (9). No strong evidence was identified in scientific literature since 2012 that likely would cause a change in DRVs.…”

Section: Methodsmentioning

confidence: 99%

Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023

Lysne,

Strandler

2023

Food & Nutrition Research

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Only a few studies have explored relationships between riboflavin intake and function and a few studies have examined the effects of supplements on various clinical or biochemical outcomes. None of these studies, however, make a useful contribution to understanding requirements in healthy populations. Thus, there is no strong evidence to change the recommendations. The requirement for riboflavin is estimated based on the relationship between intake and biochemical indices of riboflavin status, including urinary excretion and enzyme activities.

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Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values for Riboflavin

Cited by 3 publications

References 52 publications

Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

Hydrosoluble and Liposoluble Vitamins: New Perspectives through ADMET Analysis

Dietary Reference Values for riboflavin

Riboflavin: a scoping review for Nordic Nutrition Recommendations 2023

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