Literature Review of Spinal Cord Glioblastoma

Abstract

These data elucidate the characteristics of patients with scGBM. For more sophisticated and in-depth analyses in the future, it is imperative that time-of-treatment information is recorded in future case reports. In addition, all case reports should be made available to prevent publication bias.

Prolonged survival in a patient with a cervical spine H3K27M-mutant diffuse midline glioma

“…Primary GBM of the spinal cord is a rare entity, representing only 1%–3% of all spinal cord tumours 1 2. Fewer than 200 cases of spinal GBM have been reported in the literature 3. Despite continued advances, prognosis remains poor with overall survival ranging from 6 to 18 months12 with a median of 12 months 3…”

“…Fewer than 200 cases of spinal GBM have been reported in the literature 3. Despite continued advances, prognosis remains poor with overall survival ranging from 6 to 18 months12 with a median of 12 months 3…”

“…The overall survival reported of those diagnosed with H3K27M-mutant spinal cord diffuse glioma is dismal, with a median survival of 6–16 months reported across the literature,1–3 with the longest reported survival of 20 months 9 20. The low incidence of spinal cord GBM overall has resulted in a lack of clinical trials to establish the best course of treatment and management for this devastating disease.…”

“…The low incidence of primary spinal cord GBM has led to a poor understanding of the clinical characteristics and treatment options for this devastating and ultimately fatal disease. Less than 200 cases of spinal cord GBM have been presented in the literature, even fewer of which have been found to carry the histone H3K27M mutation 1–3…”

Glioblastoma Multiforme Involving Conus Medullaris in a Child

“…Hence, a maximum safe resection is a preferred approach in order to avoid post-surgical complications. Moreover, the overall survival is not altered even if a gross total resection is achieved [ 8 , 16 , 17 ].…”