Listeriaphages and coagulin C23 act synergistically to kill Listeria monocytogenes in milk under refrigeration conditions

Rodríguez-Rubio, Lorena; Garcı́a, Pilar; Rodrı́guez, Ana; Billington, Craig; Hudson, John; Martínez, Beatriz

doi:10.1016/j.ijfoodmicro.2015.04.007

Cited by 33 publications

(27 citation statements)

References 40 publications

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“…Significantly, the authors in the study concluded that the rate of development of resistance was higher when the antimicrobials were used independently, relative to the combination of the two antimicrobials together. This phenomenon of delayed resistance development could explain the synergistic effects observed in the study (Rodríguez-Rubio et al, 2015). …”

Section: Other Types Of Effective Interactions Against Pathogens Invomentioning

confidence: 64%

“…For instance, a recent study evaluated the efficacy of combinations of the class II bacteriocin coagulin C23 with listeriaphages against L. monocytogenes and found that they act in a synergistic manner against the food-borne pathogen (Rodríguez-Rubio et al, 2015). More specifically, coagulin C23 was combined with the phages FWLLm1 or FWLLm3 and synergistic effects were apparent when the two antimicrobials were mixed in sub-inhibitory concentrations.…”

Section: Other Types Of Effective Interactions Against Pathogens Invomentioning

confidence: 99%

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Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective

et al. 2017

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The continuing emergence of multi-drug resistant pathogens has sparked an interest in seeking alternative therapeutic options. Antimicrobial combinatorial therapy is one such avenue. A number of studies have been conducted, involving combinations of bacteriocins with other antimicrobials, to circumvent the development of antimicrobial resistance and/or increase antimicrobial potency. Such bacteriocin-antimicrobial combinations could have tremendous value, in terms of reducing the likelihood of resistance development due to the involvement of two distinct mechanisms of antimicrobial action. Furthermore, antimicrobial synergistic interactions may also have potential financial implications in terms of decreasing the costs of treatment by reducing the concentration of an expensive antimicrobial and utilizing it in combination with an inexpensive one. In addition, combinatorial therapies with bacteriocins can broaden antimicrobial spectra and/or result in a reduction in the concentration of an antibiotic required for effective treatments to the extent that potentially toxic or adverse side effects can be reduced or eliminated. Here, we review studies in which bacteriocins were found to be effective in combination with other antimicrobials, with a view to targeting clinical and/or food-borne pathogens. Furthermore, we discuss some of the bottlenecks which are currently hindering the development of bacteriocins as viable therapeutic options, as well as addressing the need to exercise caution when attempting to predict clinical outcomes of bacteriocin-antimicrobial combinations.

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Section: Other Types Of Effective Interactions Against Pathogens Invomentioning

confidence: 64%

Section: Other Types Of Effective Interactions Against Pathogens Invomentioning

confidence: 99%

Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective

et al. 2017

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“…Bacteriocins such as nisin have been used in meat mince to inhibit L. monocytogenes (Pawar et al 2000). Synergistic action between listeriophages and the bacteriocin coagulin C23 demonstrated inhibition of L. monocytogenes in refrigerated milk (Rodr ıguez-Rubio et al 2015). Essential oils of plant origin also have potential antimicrobial properties and can reduce Listeria survival in various products .…”

Section: Novel and Emerging Therapies To Combat Listeriosismentioning

confidence: 99%

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review

Dhama

Karthik

Tiwari

et al. 2015

Veterinary Quarterly

128

108

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Listeriosis is an infectious and fatal disease of animals, birds, fish, crustaceans and humans. It is an important food-borne zoonosis caused by Listeria monocytogenes, an intracellular pathogen with unique potential to spread from cell to cell, thereby crossing blood-brain, intestinal and placental barriers. The organism possesses a pile of virulence factors that help to infect the host and evade from host immune machinery. Though disease occurrence is sporadic throughout the world, it can result in severe damage during an outbreak. Listeriosis is characterized by septicaemia, encephalitis, meningitis, meningoencephalitis, abortion, stillbirth, perinatal infections and gastroenteritis with the incubation period varying with the form of infection. L. monocytogenes has been isolated worldwide from humans, animals, poultry, environmental sources like soil, river, decaying plants, and food sources like milk, meat and their products, seafood and vegetables. Since appropriate vaccines are not available and infection is mainly transmitted through foods in humans and animals, hygienic practices can prevent its spread. The present review describes etiology, epidemiology, transmission, clinical signs, post-mortem lesions, pathogenesis, public health significance, and advances in diagnosis, vaccines and treatment of this disease. Special attention has been given to novel as well as prospective emerging therapies that include bacteriophage and cytokine therapy, avian egg yolk antibodies and herbal therapy. Various vaccines, including advances in recombinant and DNA vaccines and their modes of eliciting immune response, are also discussed. Due focus has also been given regarding appropriate prevention and control strategies to be adapted for better management of this zoonotic disease.

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“…Some of the components of milk can act as barriers to the interaction between the bacteriophages and the host bacteria. For example, milk proteins or fat globules may interrupt a bacteriophage’s contact with the bacterial cell surface (Rodríguez-Rubio et al , 2015). …”

Section: Resultsmentioning

confidence: 99%

“…Bacteriophages are extensively distributed in all environments and can kill bacteria, so they naturally play a role in controlling bacterial populations (Hagens and Loessner, 2014; Rodríguez-Rubio et al, 2015). Bacteriophages are thought to be safe for humans, animals, and plants (Rodríguez-Rubio et al , 2015). Biocontrol strategies based on bacteriophages have received an increasing amount of interest owing to their efficacy, practicability, safety, and economic feasibility (Farber and Peterkin, 1991; Hagens and Loessner, 2007; Hagens and Loessner, 2010; Hagens and Offerhaus, 2008).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Listeria phages for Control of Growth of Listeria monocytogenes in Milk

Lee¹,

Kim²,

Lee³

et al. 2017

Korean Journal for Food Science of Animal Resources

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In this study, two Listeria bacteriophages, LMP1 and LMP7, were isolated from chicken feces as a means of biocontrol of L. monocytogenes. Both bacteriophages had a lytic effect on L. monocytogenes ATCC 7644, 15313, 19114, and 19115. Phages LMP1 and LMP7 were able to inhibit the growth of L. monocytogenes ATCC 7644 and 19114 in tryptic soy broth at 10°C and 30°C. Nevertheless, LMP1 was more effective than LMP7 at inhibiting L. monocytogenes ATCC 19114. On the contrary, LMP7 was more effective than LMP1 at inhibiting L. monocytogenes ATCC 7644. The morphology of LMP1 and LMP7 resembled that of members of the Siphoviridae family. The growth of L. monocytogenes ATCC 7644 was inhibited by both LMP1 and LMP7 in milk; however, the growth of L. monocytogenes ATCC 19114 was only inhibited by LMP1 at 30°C. The lytic activity of bacteriophages was also evaluated at 4°C in milk in order to investigate the potential use of these phages in refrigerated products. In conclusion, these two bacteriophages exhibit different host specificities and characteristics, suggesting that they can be used as a component of a phage cocktail to control L. monocytogenes in the food industry.

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Listeriaphages and coagulin C23 act synergistically to kill Listeria monocytogenes in milk under refrigeration conditions

Cited by 33 publications

References 40 publications

Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective

Bacteriocin-Antimicrobial Synergy: A Medical and Food Perspective

Listeriosis in animals, its public health significance (food-borne zoonosis) and advances in diagnosis and control: a comprehensive review

Isolation and Characterization of Listeria phages for Control of Growth of Listeria monocytogenes in Milk

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